Evidence map›Paper›PMID 33402421›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period.

Randall M Golovin, Jacob Vest, Kendal Broadie

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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  12. The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
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  20. Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Randall M GolovinVanderbilt Brain Institute.ORCID 0000-0003-1510-6126
Jacob VestDepartment of Biological Sciences.
Kendal BroadieVanderbilt Brain Institute kendal.broadie@vanderbilt.edu.ORCID 0000-0003-3783-6023
Allen Institute for Brain Science · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Genetic and Developmental Analyses of Fragile X SyndromeR01MH084989 · NIMH · VANDERBILT UNIVERSITY · PI BROADIE, KENDAL · 2009 to 2021
$5.5M
Genetic and Developmental Analyses of Fragile X Mental Retardation ProteinR56MH084989 · NIMH · VANDERBILT UNIVERSITY · PI BROADIE, KENDAL · 2023 to 2023
$516k
NICHD NIH HHS P50 HD103537NIMH NIH HHS R01 MH084989NIMH NIH HHS R56 MH084989
6 · The paper itself

Abstract

Critical periods are developmental windows during which neural circuits effectively adapt to the new sensory environment. Animal models of fragile X syndrome (FXS), a common monogenic autism spectrum disorder (ASD), exhibit profound impairments of sensory experience-driven critical periods. However, it is not known whether the causative fragile X mental retardation protein (FMRP) acts uniformly across neurons, or instead manifests neuron-specific functions. Here, we use the genetically-tractable

Indexed as

Critical Period, PsychologicalAnimalsAnimals, Genetically ModifiedDrosophilaFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeMaleNeuronal PlasticityNeuronsOdorantsOlfactory BulbOlfactory CortexOlfactory Receptor NeuronsOptogeneticsFragile X Messenger Ribonucleoprotein 1critical periodDrosophilafragile X mental retardation proteinfragile X syndromesensory experiencesynapse elimination

Identifiers

PMID33402421
PMCPMC7888229
OpenAlexW3119190776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.