Evidence map›Paper›PMID 33402420›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Impact of Acute and Persistent Excitation of Prelimbic Pyramidal Neurons on Motor Activity and Trace Fear Learning.

Timothy R Rose, Ezequiel Marron Fernandez de Velasco, Baovi N Vo, Megan E Tipps, Kevin Wickman

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  2. Article
  3. Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Timothy R RoseGraduate Program in Pharmacology.
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0003-0257-4457
Baovi N VoGraduate Program in Pharmacology.
Megan E TippsDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455 wickm002@umn.edu.ORCID 0000-0002-5179-9540
University of Minnesota · US

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI TIMOTHY J EBNER · 2020 to 2026
$19.0M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
G protein-gated K+ channels and inhibitory signalingR01MH061933 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WICKMAN, KEVIN D · 2001 to 2016
$4.4M
Relevance and plasticity of inhibitory metabotropic signaling in reward circuitsR01DA034696 · NIDA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2013 to 2022
$3.4M
Alcohol-related suppression of GIRK channel activity in the basal amygdala: a link to plasticity of glutamatergic neurotransmission and withdrawal-associated behavior?R01AA027544 · NIAAA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2020 to 2024
$1.7M
Mechanisms and relevance of the ethanol-induced suppression of inhibitory signaling in the basolateral amygdalaK01AA025978 · NIAAA · UNIVERSITY OF MINNESOTA · PI TIPPS, MEGAN E. · 2017 to 2017
$123k
NIAAA NIH HHS K01 AA025978NIAAA NIH HHS R01 AA027544NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA034696NIDA NIH HHS T32 DA007234NIMH NIH HHS R01 MH061933
6 · The paper itself

Abstract

Drug-induced neuroadaptations in the mPFC have been implicated in addictive behaviors. Repeated cocaine exposure has been shown to increase pyramidal neuron excitability in the prelimbic (PL) region of the mouse mPFC, an adaptation attributable to a suppression of G protein-gated inwardly rectifying K

Indexed as

AnimalsCocaineDopamine Uptake InhibitorsFearG Protein-Coupled Inwardly-Rectifying Potassium ChannelsLearningMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityPyramidal CellsVentral Tegmental AreaCocaineDopamine Uptake InhibitorsG Protein-Coupled Inwardly-Rectifying Potassium Channelschemogeneticscocainefear conditioningGIRKmotor activity.

Identifiers

PMID33402420
PMCPMC7880283
OpenAlexW3118728733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.