ArticleJournal of optometry
The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors.
Article in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Development of a Hyperopia Animal Model Using Blue Light in Guinea Pigs.Korean journal of ophthalmology : KJO · 2025Article
- Non-image-forming vision as measured through ipRGC-mediated pupil constriction is not modulated by covert visual attention.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The association between pupillary responses and axial length in children differs as a function of season.Scientific reports · 2024Article
- Evaluation of Disk Halo Size and Identification of Correlated Factors in Myopic Adults.Frontiers in medicine · 2022Article
- Intrinsically photosensitive retinal ganglion cell-driven pupil responses in patients with traumatic brain injury.Vision research · 2021Article
- Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.PloS one · 2021Article
- The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults.Journal of optometryArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults with various refractive errors using a custom-made optical system.
methodsPIPR was measured on myopic (-3.50 ± 1.82 D, n = 20) and non-myopic (+0.28 ± 0.23 D, n = 19) participants (mean age, 23.36 ± 3.06 years). The right eye was dilated and presented with long-wavelength (red, 625 nm, 3.68 × 10
resultsFor most subjects, the 6 s and 30 s PIPR were significantly lower (p < 0.001), and the early and late AUC were significantly larger for 1 s blue light compared to red light (p < 0.001), suggesting a strong ipRGC response. The 5 s blue stimulation induced a slightly stronger melanopsin response, compared to 1 s stimulation with the same wavelength. However, none of the PIPR metrics were different between myopes and non-myopes for either stimulus duration (p > 0.05).
conclusionsWe confirm previous research that there is no effect of refractive error on the PIPR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.