Evidence map›Paper›PMID 33402252›Full record

ArticleSleep health2021

Snoring severity is associated with carotid vascular remodeling in young adults with overweight and obesity.

Christy Taylor, Christopher E Kline, Thomas B Rice, Chunzhe Duan, Anne B Newman, Emma Barinas-Mitchell

Open access · greenAbstract read
In one paragraph

Article in Sleep health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christy TaylorSchool of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Christopher E KlineDepartment of Health and Human Development, University of Pittsburgh, Pittsburgh Pennsylvania, USA.
Thomas B RiceDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chunzhe DuanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Emma Barinas-MitchellDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: Ejb4@pitt.edu.
University of Pittsburgh · US

Funding

CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
Clinical Trail to Reverse Early Arterial StiffeningR01HL077525 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BARINAS-MITCHELL, EMMA JM · 2006 to 2010
$3.5M
A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep PhenotypK23HL118318 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, CHRISTOPHER EDWARD · 2014 to 2018
$776k
NHLBI NIH HHS K23 HL118318NHLBI NIH HHS R01 HL077525NHLBI NIH HHS T32 HL007560NHLBI NIH HHS T32 HL082610
6 · The paper itself

Abstract

backgroundSnoring is often used as a surrogate measure for obstructive sleep apnea (OSA), a sleep disorder associated with cardiovascular disease (CVD) risk. Whether snoring is linked to CVD independent of OSA remains unclear. We aimed to explore the snoring and subclinical CVD association in adults with and without OSA.

methodsWe conducted a cross-sectional study in 122 overweight/obese participants (24% male; mean age 40.1 years) attending the 24-month follow-up visit of a lifestyle intervention. Using home-based objective measures of sleep-disordered breathing, we stratified participants into 3 snoring/OSA categories using the snoring index (SI), a measure of snoring vibration, and oxygen desaturation index (ODI): (1) OSA (ODI ≥ 5), (2) non-OSA heavy snorer (ODI <5, above-median SI), and (3) non-OSA low snorer (ODI <5, below-median SI). Vascular measures including pulse wave velocity ([PWV]; carotid-femoral [cf], femoral-ankle [fa], brachial-ankle [ba]), carotid intima-media thickness (IMT), and carotid interadventitial diameter (IAD) were compared across snoring/OSA categories. Linear regressions assessed the association between snoring and subclinical CVD independent of traditional CVD risk factors.

resultsCompared to non-OSA low snorers, common carotid IMT and IAD were higher in non-OSA heavy snorers, and faPWV, IMT, and IAD were higher among those with OSA. The difference between non-OSA heavy snorers and low snorers persisted after adjusting for age, race, sex, blood pressure, body mass index, lipids, and insulin resistance (P < .05 for IMT and IAD).

conclusionsIn overweight/obese young to middle-aged adults, objectively measured snoring was related to vascular remodeling in those without OSA. Snoring may contribute to CVD risk but warrants further examination in larger prospective cohorts.

Indexed as

Carotid Intima-Media ThicknessSnoringAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedObesityOverweightProspective StudiesPulse Wave AnalysisVascular RemodelingYoung AdultCarotid intima-media thicknessObesitySleepSnoringVascular remodeling

Identifiers

PMID33402252
PMCPMC8084936
OpenAlexW3120529557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.