ArticleGenome biology2021
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease.
Open access · goldAbstract read
In one paragraph
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 1 pooled it
17.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
167 citing papers in PubMed, 1 synthesis or guideline pooled it, 255 citations in OpenAlex.
- Associations of Blood Lipids with the Risk and Prognosis of Sudden Sensorineural Hearing Loss: A Meta-analysis.The journal of international advanced otology · 2024Pooled it
- Lactylation and N6-Methyladenosine RNA modification in neuropsychiatric sequelae after intracerebral hemorrhage: a hypothesis-generating metabolic-glial-circuit framework.Molecular biology reports · 2026Review
- The YTHDF proteins modulate Alzheimer's disease-associated brain gene signatures.Molecular neurodegeneration · 2026Article
- Emerging diagnostic biomarkers and therapeutic targets in Alzheimer's disease.Inflammopharmacology · 2026Review
- Interaction between N6-methyladenosine (mGenes & diseases · 2026Review
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- Integrated multi-omics analysis identifies potential therapeutic targets for Alzheimer's disease.Neural regeneration research · 2026Article
- mNature reviews. Neuroscience · 2026Review
- N 6 -methyladenosine modification regulates cell death in cognitive impairment.Neural regeneration research · 2026Article
- Sequencing-free spatial profiling of post-transcriptional regulation in fresh tissues using nanoneedle arrays.Nature biomedical engineering · 2026Article
- The emerging role of circular RNAs in neurodegenerative diseases and viral infections.Journal of neurovirology · 2026Review
- Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms.CNS neuroscience & therapeutics · 2026Review
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
- Oleanolic acid modulates neuronal regeneration through KLF5-mediated FGF13 mRNA degradation to alleviate Alzheimer's disease-like cognitive dysfunction.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Machine Learning-Based Integration Unveils RNA Methylation Regulator-Related Immune-Derived Gene Signatures in Ruptured Intracranial Aneurysm.Biomedicines · 2026Article
- mMolecular neurobiology · 2026Article
- Single-base resolution atlas reveals moderate conservation and regulatory diversity of m6A modifications across mammals.Nucleic acids research · 2026Article
- The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.NPJ Parkinson's disease · 2026Article
- m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.The Journal of clinical investigation · 2026Article
- METTL14 regulate LRIG1 expression via m6A to affect nucleus pulposus cell senescence in intervertebral disc degeneration.Scientific reports · 2026Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Andrew M ShafikDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Feiran ZhangDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Zhenxing GuoDepartment of Biostatistics and Bioinformatics, School of Public Health, Emory University, Atlanta, GA, 30322, USA.
Qing DaiDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
Kinga PajdzikDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
Yangping LiDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Yunhee KangDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Bing YaoDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Hao WuDepartment of Biostatistics and Bioinformatics, School of Public Health, Emory University, Atlanta, GA, 30322, USA.
Chuan HeDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
Emily G AllenDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Ranhui DuanCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Peng JinDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA. peng.jin@emory.edu.ORCID 0000-0001-6137-6659
Emory University · USUniversity of Chicago · USCentral South University · CN
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MMolecular Basis of rCGG-Mediated NeurodegenerationR01NS051630 · NINDS · EMORY UNIVERSITY · PI NELSON, DAVID LOREN · 2006 to 2023
$9.8MDynamic DNA Modifications in Brain and DiseasesR35NS111602 · NINDS · EMORY UNIVERSITY · PI PENG JIN · 2019 to 2026
$6.5MDynamic RNA Modifications in human brain development and autismU01MH116441 · NIMH · EMORY UNIVERSITY · PI JIN, PENG · 2018 to 2022
$4.9MGenome-wide mapping and integrative analysis of DNA 6mA methylome in human AD brainR01AG064786 · NIA · UNIVERSITY OF FLORIDA · PI BENNETT, DAVID ALAN, YAO, BING · 2019 to 2023
$3.3MEpigenetic roles of DNA adenine methylation in stress responseR01MH117122 · NIMH · EMORY UNIVERSITY · PI YAO, BING · 2019 to 2023
$2.0MEpigenetic roles of DNA adenine methylation in Alzheimer's DiseaseR01AG062577 · NIA · EMORY UNIVERSITY · PI YAO, BING · 2019 to 2023
$2.0MNHGRI NIH HHS HG008935NHGRI NIH HHS RM1 HG008935NIA NIH HHS R01 AG062577NIA NIH HHS R01 AG064786NIH HHS NS051630, NS111602, MH116441NIMH NIH HHS R01 MH117122NIMH NIH HHS U01 MH116441NINDS NIH HHS R01 NS051630NINDS NIH HHS R35 NS111602
Abstract
backgroundN6-methyladenosine (m
resultsWe show that m
conclusionsOur results suggest that m
Indexed as
AdenosineAgingAlzheimer DiseaseAnimalsBrainDisease Models, AnimalDrosophilaDrosophila ProteinsHumansMethylationMethyltransferasesMiceNeurodegenerative DiseasesRNA StabilityAdenosineDrosophila ProteinsMethyltransferasesMettl3 protein, DrosophilaN-methyladenosineAgingAlternative 3′UTRAlzheimer’sEpitranscriptomicsm6ANeurodevelopmentRegulation of mRNA levelsRegulation of protein levels
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.