ArticleJournal of translational medicine2021
Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump.
Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Guideline
- Extracorporeal COCritical care (London, England) · 2026Trial
- Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps.Artificial organs · 2026Article
- Post-Market Analysis of the Xenios Console With the Xlung Tubing Kit 230 for Extracorporeal Membrane Oxygenation After Cardiac Surgery.Artificial organs · 2026Article
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- Challenges and opportunities in ECMO monitoring: A mixed-methods appraisal.The journal of extra-corporeal technology · 2026Review
- Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep.Annals of biomedical engineering · 2026Article
- Comparison of a Miniaturized Implantable Two-Stage Rotodynamic Blood Pump to Equivalent Single-Stage Concepts.Artificial organs · 2026Article
- Considerations and future challenges in managing ECMO for pediatric patients.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Review
- Standardization ofPerfusion · 2026Review
- Numerical Analyses of Blood Pumps Under Realistic Operating Conditions.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Standardization of In Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.Artificial organs · 2026Review
- Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.Interdisciplinary cardiovascular and thoracic surgery · 2026Review
- High-Caliber Femoral Dual-Lumen Cannula for ECCO 2 R in Hypercapnic Respiratory Failure: Efficacy and Safety Evaluation.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Multimodal characterization of flow-induced thrombus initiation and growth in extracorporeal membrane oxygenation.Scientific reports · 2026Article
- Prediction of Long-Term Mortality in Acute Hypercapnic Respiratory Failure with Use of Low-Flow Veno-Venous Extracorporeal COBlood purification · 2026Article
- One trigger, two fates: hemolysate shapes neutrophil extracellular traps (NETs) formation in a context-dependent manner.Frontiers in immunology · 2026Article
- Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure.Bioactive materials · 2025Article
- Material-Induced Platelet Adhesion/Activation and Hemolysis of Membrane Lung Components from Extracorporeal Membrane Oxygenation.Biomedicines · 2025Article
- Development of a Protocol for Long-Term Ex Vivo Normothermic Machine Perfusion of Rodent Livers.Artificial organs · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients receiving ECMO, and patients undergoing extracorporeal CO
methodsIn this study, the hemolysis of the centrifugal pump DP3 is evaluated both in vitro and in silico, comparing the low-flow operation at 1 L/min to the high-flow operation at 4 L/min.
resultsIncreased hemolysis occurs at low-flow, both in vitro and in silico. The in-vitro experiments present a sixfold higher relative increased hemolysis at low-flow. Compared to high-flow operation, a more than 3.5-fold increase in blood recirculation within the pump head can be observed in the low-flow range in silico.
conclusionsThis study highlights the underappreciated hemolysis in centrifugal pumps within the low-flow range, i.e. during pediatric ECMO or ECCO
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