ArticleBMC cancer2021
Actual long-term survival after resection of stage III soft tissue sarcoma.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Systematic review of 99 extremity bone malignancy survival prediction models.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Pooled it
- Feasibility and therapeutic potential of [European journal of nuclear medicine and molecular imaging · 2024Trial
- Soft Tissue Sarcoma Burden and Research Productivity: Global Patterns and Disparities, 1990-2021.Health science reports · 2026Article
- Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma.Toxins · 2025Article
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- Resection of primary left renal vein leiomyosarcoma with renal preservation following an unusual clinical presentation.BMJ case reports · 2024Article
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- Organoids as a new approach for improving pediatric cancer research.Frontiers in oncology · 2024Review
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- Radiotherapy, volume reduction, and short-term surgical outcomes in the treatment of large myxoid liposarcomas.Radiation oncology journal · 2022Article
- Descriptive epidemiology of soft tissue sarcomas and gastrointestinal stromal tumors in Thailand.Scientific reports · 2022Article
- Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis.Cureus · 2022Article
- Giant bleeding post-traumatic thoracic sarcoma management: A case report.Frontiers in surgery · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActuarial survival based on the Kaplan-Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS.
methodsWe retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years.
resultsMultivariate logistic regression analyses showed that a tumor size < 10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size > 10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival.
conclusionsActual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.
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