Evidence map›Paper›PMID 33401776›Full record

ArticleInternational journal of molecular sciences2021

Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5' Terminal Regions.

Corey Nelson, Tyler Mrozowich, Darren L Gemmill, Sean M Park, Trushar R Patel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Human lncRNAProceedings of the National Academy of Sciences of the United States of America · 2026
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  12. Editorial of Special Issue "Non-Coding RNAs in Pathogen-Host Interaction".International journal of molecular sciences · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Corey NelsonDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada.ORCID 0000-0001-6604-8566
Tyler MrozowichDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada.ORCID 0000-0002-1077-9682
Darren L GemmillDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada.
Sean M ParkDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada.ORCID 0000-0003-1334-9247
Trushar R PatelDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada.ORCID 0000-0003-0627-2923
University of Lethbridge · CA

Funding

Canada Foundation for Innovation 37155Natural Sciences and Engineering Research Council of Canada RGPIN-2017-04003
6 · The paper itself

Abstract

Flavivirus genus includes many deadly viruses such as the Japanese encephalitis virus (JEV) and Zika virus (ZIKV). The 5' terminal regions (TR) of flaviviruses interact with human proteins and such interactions are critical for viral replication. One of the human proteins identified to interact with the 5' TR of JEV is the DEAD-box helicase, DDX3X. In this study, we in vitro transcribed the 5' TR of JEV and demonstrated its direct interaction with recombinant DDX3X (K

Indexed as

5' Untranslated RegionsDEAD-box RNA HelicasesEncephalitis Virus, JapaneseGene ExpressionHost Microbial InteractionsHumansProtein DomainsUp-RegulationVirus ReplicationZika Virus5' Untranslated RegionsDDX3X protein, humanDEAD-box RNA HelicasesDDX3Xhost–viral interactionsin vitro transcriptionJapanese encephalitis virusmicroscale thermophoresisRNA helicase assaysviral terminal regionsZika virus

Identifiers

PMID33401776
PMCPMC7795613
OpenAlexW3120032774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.