Evidence map›Paper›PMID 33401735›Full record

ArticleJournal of clinical medicine2021

Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19.

Maura M Zylla, Uta Merle, Johannes A Vey, Grigorios Korosoglou, Eva Hofmann, Michael Müller, Felix Herth, Werner Schmidt, Erwin Blessing, Christoph Göggelmann and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  17. Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients?The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Maura M ZyllaDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Uta MerleDepartment of Gastroenterology, Hepatology and Infectious Disease, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID 0000-0003-1386-3350
Johannes A VeyInstitute of Medical Biometry and Informatics, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.ORCID 0000-0002-2610-9667
Grigorios KorosoglouGRN Klinikum Weinheim, Klinik für Kardiologie, Angiologie und Pneumologie, Röntgenstraße 1, 69469 Weinheim, Germany.
Eva HofmannDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Michael MüllerDepartment of Pulmonary and Respiratory Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Röntgenstr. 1, 69126 Heidelberg, Germany.
Felix HerthDepartment of Pulmonary and Respiratory Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Röntgenstr. 1, 69126 Heidelberg, Germany.
Werner SchmidtDepartment of Anaesthesiology, Intensive Care, Pain Therapy, Thoraxklinik, Heidelberg University Hospital, Röntgenstr. 1, 69126 Heidelberg, Germany.
Erwin BlessingSRH Klinikum Karlsbad-Langensteinbach, Abteilung für Innere Medizin, Guttmannstraße 1, 76307 Karlsbad, Germany.
Christoph GöggelmannDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Norbert WeidnerSpinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.
Mascha O FiedlerDepartment of Anaesthesiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.ORCID 0000-0002-0127-2783
Markus A WeigandDepartment of Anaesthesiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
Florian KälbleNierenzentrum Heidelberg, Department of Nephrology, Heidelberg University Hospital, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany.
Christian MorathNierenzentrum Heidelberg, Department of Nephrology, Heidelberg University Hospital, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany.
Johannes LeinerDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Meinhard KieserInstitute of Medical Biometry and Informatics, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.
Hugo A KatusDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Dierk ThomasDepartment of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Heidelberg University · DEZimmer Biomet (Germany) · DESiloah St. Trudpert Klinikum · DESRH Klinikum Karlsbad-Langensteinbach · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role of cardiac arrhythmias in COVID-19 is insufficiently understood. This study assesses the incidence of cardiac arrhythmias and their prognostic implications in hospitalized COVID-19-patients.

methodsA total of 166 patients from eight centers who were hospitalized for COVID-19 from 03/2020-06/2020 were included. Medical records were systematically analyzed for baseline characteristics, biomarkers, cardiac arrhythmias and clinical outcome parameters related to the index hospitalization. Predisposing risk factors for arrhythmias were identified. Furthermore, the influence of arrhythmia on the course of disease and related outcomes was assessed using univariate and multiple regression analyses.

resultsArrhythmias were detected in 20.5% of patients. Atrial fibrillation was the most common arrhythmia. Age and cardiovascular disease were predictors for new-onset arrhythmia. Arrhythmia was associated with a pronounced increase in cardiac biomarkers, prolonged hospitalization, and admission to intensive- or intermediate-care-units, mechanical ventilation and in-hospital mortality. In multiple regression analyses, incident arrhythmia was strongly associated with duration of hospitalization and mechanical ventilation. Cardiovascular disease was associated with increased mortality.

conclusionsArrhythmia was the most common cardiac event in association with hospitalization for COVID-19. Older age and cardiovascular disease predisposed for arrhythmia during hospitalization. Whereas in-hospital mortality is affected by underlying cardiovascular conditions, arrhythmia during hospitalization for COVID-19 is independently associated with prolonged hospitalization and mechanical ventilation. Thus, incident arrhythmia may indicate a patient subgroup at risk for a severe course of disease.

Indexed as

arrhythmiaatrial fibrillationCOVID-19hospitalizationrisk stratification

Identifiers

PMID33401735
PMCPMC7796041
OpenAlexW3119717317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.