Evidence map›Paper›PMID 33401565›Full record

ArticleMicroorganisms2021

SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.

Camilla Bitossi, Federica Frasca, Agnese Viscido, Giuseppe Oliveto, Mirko Scordio, Laura Belloni, Giuseppe Cimino, Valeria Pietropaolo, Massimo Gentile, Gabriella d'Ettorre and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  5. Review
  6. Expression ofAmerican journal of respiratory cell and molecular biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Camilla BitossiLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Federica FrascaLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Agnese ViscidoLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Giuseppe OlivetoLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Mirko ScordioLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Laura BelloniDepartment of Internal Medicine, Sapienza University, 00161 Rome, Italy.
Giuseppe CiminoLazio Reference Center for Cystic Fibrosis, Policlinico Umberto I University Hospital, Sapienza University, 00161 Rome, Italy.
Valeria PietropaoloDepartment of Public Health and Infectious Diseases, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-5723-8886
Massimo GentileLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-3571-5677
Fabio MidullaDepartment of Maternal Science, Sapienza University of Rome, 00161 Rome, Italy.
Maria TrancassiniDepartment of Public Health and Infectious Diseases, Sapienza University, 00161 Rome, Italy.
Guido AntonelliLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-0633-360X
Carolina ScagnolariLaboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-1044-1478
Istituto Pasteur · ITPoliclinico Umberto I · ITSapienza University of Rome · IT

Funding

Fondazione per la Ricerca sulla Fibrosi Cistica FFC#14/2018Ministero della Salute COVID-2020-12371817Sapienza Università di Roma Fondi Progetti di ricerca universitaria 2018 RM118164305BABF8
6 · The paper itself

Abstract

The expression rate of SARS-CoV-2 entry genes, angiotensin-converting enzyme 2 (ACE2), the main viral receptor and the proteases, furin and transmembrane serine protease 2 (TMPRSS2) in cystic fibrosis (CF) individuals is poorly known. Hence, we examined their levels in upper respiratory samples of CF patients (

Indexed as

ACE2cystic fibrosisdACE2furininterferonISG15SARS-CoV-2TMPRSS2

Identifiers

PMID33401565
PMCPMC7824643
OpenAlexW3120161007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.