Evidence map›Paper›PMID 33401546›Full record

ArticleJournal of clinical medicine2021

A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results.

Mauro Cozzolino, Stefania Cocco, Michela Piezzo, Giovanna Celia, Susan Costantini, Valentina Abate, Francesca Capone, Daniela Barberio, Laura Girelli, Elisa Cavicchiolo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mauro CozzolinoDepartment of Human, Philosophical and Educational Sciences, University of Salerno, 84084 Fisciano (SA), Italy.ORCID 0000-0002-3195-6916
Stefania CoccoDepartment of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0003-3169-1580
Michela PiezzoDepartment of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-1730-3900
Giovanna CeliaDepartment of Human, Philosophical and Educational Sciences, University of Salerno, 84084 Fisciano (SA), Italy.
Susan CostantiniExperimental Pharmacology Unit-Mercogliano Laboratory, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-7538-4657
Valentina AbatePsychology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Francesca CaponeExperimental Pharmacology Unit-Mercogliano Laboratory, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Daniela BarberioPsychology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Laura GirelliDepartment of Human, Philosophical and Educational Sciences, University of Salerno, 84084 Fisciano (SA), Italy.
Elisa CavicchioloDepartment of Human, Philosophical and Educational Sciences, University of Salerno, 84084 Fisciano (SA), Italy.ORCID 0000-0001-8552-2737
Paolo Antonio AsciertoDepartment Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-8322-475X
Gabriele MadonnaDepartment Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-9395-3190
Alfredo BudillonExperimental Pharmacology Unit-Mercogliano Laboratory, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-6631-3550
Michelino De LaurentiisDepartment of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-9009-1572
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression, metastasis, and therapeutic outcome. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Recent findings suggest that positive psychosocial experiences, including psychotherapeutic interventions and therapeutic mind-body protocols, can modulate the inflammatory response by reducing the expression of genes/proteins associated with inflammation and stress-related pathways. Our preliminary results indicate that a specific mind-body therapy (MBT-T) could induce a significant reduction of the release of different cytokines and chemokines, such as SCGFβ, SDF-1α, MCP3, GROα, LIF, and IL-18, in the sera of breast cancer patients compared to a control group, suggesting that MBT-T could represent a promising approach to improve the wellness and outcome of breast cancer patients.

Indexed as

breast cancercytokinesinflammationmind-body transformations therapy (MBT-T)

Identifiers

PMID33401546
PMCPMC7796278
OpenAlexW3120899641

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.