Evidence map›Paper›PMID 33401515›Full record

ReviewInternational journal of molecular sciences2021

On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors.

Mariangela Pucci, Elizabeta Zaplatic, Maria Vittoria Micioni Di Bonaventura, Emanuela Micioni Di Bonaventura, Paolo De Cristofaro, Mauro Maccarrone, Carlo Cifani, Claudio D'Addario

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Association betweenJournal of medicine and life · 2023
    Article
  6. Genes · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival.International journal of molecular sciences · 2021
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mariangela PucciFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.ORCID 0000-0003-4657-6075
Elizabeta ZaplaticFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.
Maria Vittoria Micioni Di BonaventuraPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy.ORCID 0000-0002-8044-1206
Emanuela Micioni Di BonaventuraPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy.ORCID 0000-0001-8484-7513
Paolo De CristofaroClinical Endocrinology and Metabolism Outpatient Clinic, 64021 Giulianova TE, Italy.
Mauro MaccarroneDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila AQ, Italy.ORCID 0000-0002-3990-2963
Carlo CifaniPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy.ORCID 0000-0001-6180-828X
Claudio D'AddarioFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.
Università di Camerino · ITUniversity of Teramo · ITUniversity of L'Aquila · IT

Funding

Marie Skłodowska-Curie grant agreement no. 713714 (Rep-Eat - H2020-MSCACOFUND-2015 713714
6 · The paper itself

Abstract

Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.

Indexed as

Feeding BehaviorGene Expression RegulationAnimalsHumansMicePromoter Regions, GeneticRatsReceptor, Cannabinoid, CB1Transcription, GeneticCNR1 protein, humanCNR1 protein, mouseCnr1 protein, ratReceptor, Cannabinoid, CB1eating behaviorsfood intaketranscriptional regulationtype-1 cannabinoid receptor gene

Identifiers

PMID33401515
PMCPMC7796374
OpenAlexW3114212084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.