ArticleBiomedicines2021
Subcutaneous Implantation Assessment of New Calcium-Silicate Based Sealer for Warm Obturation.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Surgical management of massive calcium silicate-based sealer extrusion into the maxillary sinus with palatal necrosis in an adolescent.BMC oral health · 2026Article
- Bond Strength of an Epoxy Resin Root Canal Sealer Prototype.Dentistry journal · 2025Article
- Cytotoxicity and subcutaneous tissue response of beta RCS in comparison with ADSeal and AH plus endodontic sealers: in vitro/in vivo study.The Saudi dental journal · 2025Article
- Long-Term Stability and Osteogenic Activity of Recycled Polysulfone-Calcium Silicate Bone Implants In Vitro.Journal of functional biomaterials · 2025Article
- Retreatability of calcium silicate-based sealers based on micro-computed tomographic evaluation - A systematic review.The Saudi dental journal · 2024Review
- Biocompatibility, bioactivity and immunomodulatory properties of three calcium silicate-based sealers: an in vitro study on hPDLSCs.Clinical oral investigations · 2024Article
- Evaluation of the antibacterial and cytotoxic properties of TotalFill and NeoSEALER flo bioceramic sealers.Journal of conservative dentistry and endodontics · 2024Article
- Premixed calcium silicate-based root canal sealers have better biological properties than AH Plus: A systematic review and meta-analysis of in vivo animal studies andJournal of conservative dentistry and endodontics · 2024Review
- The osteoinductive potential of different root-end filling materials in a rat femur modelScientific reports · 2024Article
- Article
- Evaluation of Cytotoxicity, Cell Attachment, and Elemental Characterization of Three Calcium Silicate-Based Sealers.Materials (Basel, Switzerland) · 2023Article
- Biocompatibility, Biomineralization and Induction of Collagen Maturation with the Use of Calcium Hydroxide and Iodoform Intracanal Dressing.Journal of functional biomaterials · 2023Article
- Comparison sealing ability in three bioceramic sealers applied in hydraulic condensation technique by using micro-computed tomography.Journal of dental sciences · 2023Article
- Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants.Journal of functional biomaterials · 2023Article
- Cytotoxicity and Mineralization Activity of Calcium Silicate-Based Root Canal Sealers Compared to Conventional Resin-Based Sealer in Human Gingival Fibroblast Cells.International journal of dentistry · 2023Article
- Bioprinting and biomaterials for dental alveolar tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Biological investigation of resinous endodontic sealers containing calcium hydroxide.PloS one · 2023Article
- Bioactivity Potential of Bioceramic-Based Root Canal Sealers: A Scoping Review.Life (Basel, Switzerland) · 2022Article
- Subcutaneous Tissue Response to Adseal and Sure-Seal Root Sealers in Rats: a Histopathological Study.Maedica · 2022Article
- Dentin Sealing of Calcium Silicate-Based Sealers in Root Canal Retreatment: A Confocal Laser Microscopy Study.Journal of functional biomaterials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium silicate-based sealers were recently introduced as a new class of endodontic sealers, with potential further benefits due to their bioactivity. The aim of this study was to evaluate the biocompatibility of two new hydraulic calcium silicate-based sealers, TotalFill BC Sealer (FKG, La Chaux-des-Fonds, Switzerland) and TotalFill BC Sealer HiFlow (FKG, La Chaux-des-Fonds, Switzerland) through subcutaneous implantation in connective tissue of rats. Subcutaneous implantation was performed in 16 young Wistar rats. Four polyethylene tubes were implanted in each animal, one empty to serve as a control, and three filled with tested sealers: AH Plus as reference (Dentsply DeTrey, Konstanz, Germany), TotalFill BC Sealer (BC) and TotalFill BC Sealer HiFlow (HiFlow). Eight rats were euthanized at 8 days and the remaining eight at 30 days. Hematoxylin-eosin staining was used to score the inflammatory reaction, macrophage infiltrate and to measure the thickness of the fibrous capsule. von Kossa staining was performed to evaluate the mineralization level. Kruskal-Wallis test followed by Dunn's
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.