Evidence map›Paper›PMID 33401390›Full record

ArticleBrain sciences2021

One-Year Follow-Up Diagnostic Stability of Autism Spectrum Disorder Diagnosis in a Clinical Sample of Children and Toddlers.

Loredana Benedetto, Francesca Cucinotta, Roberta Maggio, Eva Germanò, Roberta De Raco, Ausilia Alquino, Caterina Impallomeni, Rosamaria Siracusano, Luigi Vetri, Michele Roccella and 2 more

Abstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Systematic review of measures and interventions for caregiver adjustment to child autism diagnosis.Autism : the international journal of research and practice · 2026
    Pooled it
  2. Pooled it
  3. Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Article
  5. Article
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  8. Canonical babbling trajectories across the first year of life in autism and typical development.Autism : the international journal of research and practice · 2024
    Article
  9. Article
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  11. Article
  12. On the Waves of the COVID-19 Pandemic.Journal of clinical medicine · 2023
    Article
  13. Review
  14. Epilepsy: A Multifaced Spectrum Disorder.Behavioral sciences (Basel, Switzerland) · 2023
    Article
  15. Journal of clinical medicine · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Loredana BenedettoDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0001-6957-2224
Francesca CucinottaDivision of Child Neurology and Psychiatry, Department of the Adult and Developmental Age Human Pathology, University of Messina, 98122 Messina, Italy.
Roberta MaggioDivision of Child Neurology and Psychiatry, Department of the Adult and Developmental Age Human Pathology, University of Messina, 98122 Messina, Italy.
Eva GermanòDivision of Child Neurology and Psychiatry, Department of the Adult and Developmental Age Human Pathology, University of Messina, 98122 Messina, Italy.
Roberta De RacoDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Ausilia AlquinoDivision of Child Neurology and Psychiatry, Department of the Adult and Developmental Age Human Pathology, University of Messina, 98122 Messina, Italy.
Caterina ImpallomeniDivision of Child Neurology and Psychiatry, Department of the Adult and Developmental Age Human Pathology, University of Messina, 98122 Messina, Italy.
Rosamaria SiracusanoDivision of Child Neurology and Psychiatry, Federico II University Hospital Naples, 80131 Napoli, Italy.
Luigi VetriDepartment of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-0121-3396
Michele RoccellaDepartment of Psychology, Educational Science and Human Movement, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-7371-0228
Massimo IngrassiaDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0003-0407-4480
Antonella GaglianoChild & Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, 09123 Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some studies show that the diagnosis of Autism Spectrum Disorder could be considered reliable and stable in children aged 18 to 24 months. Nevertheless, the diagnostic stability of early ASD diagnosis has not yet been fully demonstrated. This observational study examines the one-year diagnostic stability of autism spectrum disorder diagnosis in a clinical sample of 147 children diagnosed between 18 and 48 months of age. The ADOS-2 scores were used in order to stratify children in three levels of symptom severity: Autism (AD; comparison score 5-7), Autism Spectrum Disorder (ASD; comparison score 3-4), and Sub-Threshold Symptoms; (STS; comparison score 1-2). Results: Overall, the largest part of children and toddlers diagnosed with autism spectrum disorder between 18 and 48 months continued to show autistic symptoms at one-year follow-up evaluation. Nevertheless, a significant percentage of children with higher ADOS severity scores exhibited a reduction of symptom severity and, therefore, moved towards a milder severity class one year later. Conversely, the number of subjects of the STS group meaningfully increased. Therefore, at one-year follow-up a statistically significant (χ

Indexed as

autism spectrum disorderbehavioral treatmentdiagnostic stabilityfollow-up

Identifiers

PMID33401390
PMCPMC7823497

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.