Evidence map›Paper›PMID 33401137›Full record

ArticleNeuroImage. Clinical2021

Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.

Jonathan M DuBois, Sulantha Mathotaarachchi, Olivier G Rousset, Viviane Sziklas, Jorge Sepulcre, Marie-Christine Guiot, Jeffery A Hall, Gassan Massarweh, Jean-Paul Soucy, Pedro Rosa-Neto and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  5. Review
  6. Neuropsychiatric disease and treatment · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jonathan M DuBoisDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address: jonathan.dubois@biogen.com.
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Canada.
Olivier G RoussetDivision of Nuclear Medicine and Molecular Imaging, Johns Hopkins University, Baltimore, United States.
Viviane SziklasDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Jorge SepulcreGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Marie-Christine GuiotDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada; Department of Pathology, McGill University, Montreal, Canada.
Jeffery A HallDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Gassan MassarwehDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Jean-Paul SoucyPET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada; Bio-Imaging Group, PERFORM Centre, Concordia University, Montreal, Canada.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada; Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Canada; PET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.
Eliane KobayashiDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address: eliane.kobayashi@mcgill.ca.
Montreal Neurological Institute and Hospital · CADouglas Mental Health University Institute · CAHarvard University · USJohns Hopkins University · US

Funding

CIHR MOP-115131CIHR MOP-93614
6 · The paper itself

Abstract

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [

Indexed as

EpilepsyMalformations of Cortical DevelopmentBrainCarbon RadioisotopesHumansPositron-Emission TomographyCarbon RadioisotopesEpilepsyFCDmGluR5NetworkPET

Identifiers

PMID33401137
PMCPMC7787952
OpenAlexW3117753736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.