SynthesisDrug and alcohol dependence2021
Prevalence of childhood maltreatment among people with opioid use disorder: A systematic review and meta-analysis.
Synthesis in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- A review of the 257 meta-analyses of the differences between females and males in prevalence and risk, protective factors, and treatment outcomes for mental disorder.BMC psychiatry · 2025Pooled it
- Increased Prevalence of Childhood Complex Trauma in Comorbid Posttraumatic Stress Disorder and Substance Use Disorders Compared to Either Disorder Alone: A Systematic Review.Early intervention in psychiatry · 2025Pooled it
- Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Trauma exposure across the lifespan among individuals engaged in treatment with medication for opioid use disorder: differences by gender, PTSD status, and chronic pain.Substance abuse treatment, prevention, and policy · 2024Trial
- Adverse Effects of Non-Medical Use of Cannabis or Opioids Associated with Adverse Childhood Experiences.International journal of environmental research and public health · 2026Article
- Factors Associated With Opioid Agonist Treatment Engagement and Harm Reduction Service Use: Findings From the New South Wales Opioid Dependence Survey.Drug and alcohol review · 2026Article
- Augmenting Missing Individual Social Determinants of Health with Area-Level Social Deprivation Index for Gene-Environment Interaction: Application to Opioid Use Disorder Prediction.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026Article
- Assessing behavioural economic demand for morphine after an acute dose in individuals with- and without childhood trauma: a double-blind, randomised, controlled trial.Psychopharmacology · 2025Article
- The Role of Child Maltreatment and Revictimization on Substance Use Trajectories Among Women Involved in the Criminal Justice System.Women & criminal justice · 2025Article
- Characterization of inflammatory and neurofunctional markers in the context of early life stress among a clinical sample of people maintained on buprenorphine for opioid use disorder.Brain, behavior, & immunity - health · 2025Article
- Gender differences regarding interest in opioid agonist treatment with hydromorphone: a cross-sectional study of syringe service program participants.Harm reduction journal · 2025Article
- Mechanisms of childhood trauma: an integrative review of a multimodal, transdiagnostic pathway.Neurobiology of stress · 2025Review
- Helping Opioid Use Disorder and PTSD with Exposure (HOPE): An Open-Label Pilot Study of a Trauma-Focused, Integrated Therapy for OUD/PTSD.Behavioral sciences (Basel, Switzerland) · 2025Article
- The Relationship Between Childhood Sexual Abuse and Executive Function for Those in Recovery from Opioid Use Disorder: A Brief Report of a Pilot Study.Journal of family violence · 2025Article
- Exploring social impairment in those with opioid use disorder: linking impulsivity, childhood trauma, and the prefrontal cortex.BMC psychiatry · 2025Article
- Understanding Black and Latino sexual minority men's perspectives on assessment of sexual history in diverse health care settings.Psychological trauma : theory, research, practice and policy · 2025Article
- Opioid Addiction and Gender Role Conflict: A Comparative Study of Fathers Receiving Treatment for an Opioid Use Disorder.Psychology of men & masculinity · 2025Article
- "Tethered to this ball and chain": Women's perspectives on bodily agency within opioid treatment programs.The International journal on drug policy · 2024Article
- Sex differences in comorbid pain and opioid use disorder: A scoping review.British journal of clinical pharmacology · 2024Article
- Immediate Effects of Mindful Awareness in Body-Oriented Therapy as an Adjunct to Medication for Opioid Use Disorder.Mindfulness · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExperience of childhood maltreatment (CM) is a risk factor for opioid use disorder (OUD). CM is also associated with comorbid mental disorders and poor treatment outcomes among people with OUD. To our knowledge, this is the first systematic review and meta-analysis to estimate the prevalence of CM among people with OUD.
methodsWe searched MEDLINE, EMBASE, and PsycINFO to identify observational studies that evaluated CM among people with OUD from January 1990 to June 2020. Prevalence of each CM type, sample characteristics, and methodological factors were extracted from each eligible study. Random-effects meta-analyses were used to pool prevalence estimates. Stratified meta-analyses were used to assess heterogeneity.
resultsOf the 6,438 publications identified, 113 studies reported quantitative CM data among people with OUD and 62 studies (k = 62; N = 21,871) were included in primary analyses. Among people with OUD, the estimated prevalence of sexual abuse was 41% (95% CI 36-47%; k = 38) among women and 16% (95% CI 12-20%; k = 25) among men. Among all people with OUD, prevalence estimates were 38% (95% CI 33-44%; k = 48) for physical abuse, 43% (95% CI 38-49%; k = 31) for emotional abuse, 38% (95% CI 30-46%; k = 17) for physical neglect, and 42% (95% CI 32-51%; k = 17) for emotional neglect. Sex, history of injecting drug use, recruitment methods, and method of assessing CM were associated with substantial heterogeneity.
conclusionsPeople with OUD frequently report the experience of CM, supporting the need for trauma-informed interventions among this population. Future research should consider the impact of CM on OUD presentations and when assessment is appropriate, use of validated instruments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.