Evidence map›Paper›PMID 33400641›Full record

ArticleMicrobiology (Reading, England)2021

Multiple holins contribute to extracellular DNA release in

Amelia L Hynen, James J Lazenby, George M Savva, Laura C McCaughey, Lynne Turnbull, Laura M Nolan, Cynthia B Whitchurch

Open access · hybridAbstract read
In one paragraph

Article in Microbiology (Reading, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Metal-independent effects of calprotectin on cocultures ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Co-infection withISME communications · 2026
    Article
  5. Single-cell lysis patterns morphogenesis of eDNA in the matrix ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Biochemistry · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Mechanisms of antimicrobial resistance in biofilms.npj antimicrobials and resistance · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis inFrontiers in cellular and infection microbiology · 2023
    Article
  19. eDNA, Amyloid Fibers and Membrane Vesicles Identified inInternational journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Amelia L HynenThe ithree institute, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
James J LazenbyThe ithree institute, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
George M SavvaQuadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
Laura C McCaugheyThe ithree institute, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
Lynne TurnbullThe ithree institute, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
Laura M NolanNational Heart and Lung Institute, Imperial College London, London, SW3 6LR, UK.
Cynthia B WhitchurchThe ithree institute, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
University of Technology Sydney · AUImperial College London · GBNorwich Research Park · GBUniversity of East Anglia · GB

Funding

Biotechnology and Biological Sciences Research Council BB/CCG1860/1Biotechnology and Biological Sciences Research Council BB/R012504/1Wellcome TrustWellcome Trust 106064/Z/14/2
6 · The paper itself

Abstract

Bacterial biofilms are composed of aggregates of cells encased within a matrix of extracellular polymeric substances (EPS). One key EPS component is extracellular DNA (eDNA), which acts as a 'glue', facilitating cell-cell and cell-substratum interactions. We have previously demonstrated that eDNA is produced in

Indexed as

Bacterial ProteinsBacteriolysisBiofilmsDNA, BacterialEndopeptidasesExtracellular Polymeric Substance MatrixMutationPseudomonas aeruginosaBacterial ProteinsDNA, BacterialendolysinEndopeptidasesbiofilm initiationEPSexplosive cell lysisextracellular polymeric substancemicrocolony formation

Identifiers

PMID33400641
PMCPMC8131026
OpenAlexW3120932737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.