Evidence map›Paper›PMID 33400606›Full record

ArticleJournal of computational biology : a journal of computational molecular cell biology2021

NetMix: A Network-Structured Mixture Model for Reduced-Bias Estimation of Altered Subnetworks.

Matthew A Reyna, Uthsav Chitra, Rebecca Elyanow, Benjamin J Raphael

Open access · greenAbstract read
In one paragraph

Article in Journal of computational biology : a journal of computational molecular cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. Article
  6. NetMix2: A Principled Network Propagation Algorithm for Identifying Altered Subnetworks.Journal of computational biology : a journal of computational molecular cell biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew A ReynaDepartment of Biomedical Informatics, Emory University, Atlanta, Georgia, USA.
Uthsav ChitraDepartment of Computer Science, Princeton University, Princeton, New Jersey, USA.
Rebecca ElyanowDepartment of Computer Science, Princeton University, Princeton, New Jersey, USA.
Benjamin J RaphaelDepartment of Computer Science, Princeton University, Princeton, New Jersey, USA.
Princeton University · USEmory University · US

Funding

Systematic discovery of neomorph protein-protein interactions in cancer for oncogenic pathway perturbationU01CA217875 · NCI · EMORY UNIVERSITY · PI FU, HAIAN · 2017 to 2021
$4.5M
Pathway and Network Integration of Cancer Genomics and Clinical DataU24CA211000 · NCI · PRINCETON UNIVERSITY · PI RAPHAEL, BENJAMIN, YEH, JEN JEN · 2016 to 2020
$1.7M
Computational Characterization of Genetic HeterogeneityR01HG007069 · NHGRI · PRINCETON UNIVERSITY · PI RAPHAEL, BENJAMIN · 2013 to 2015
$1.1M
NCI NIH HHS U01 CA217875NCI NIH HHS U24 CA211000NHGRI NIH HHS R01 HG007069
6 · The paper itself

Abstract

A classic problem in computational biology is the identification of

Indexed as

AlgorithmsBiasComputational BiologyLikelihood FunctionsModels, Statisticalaltered subnetworks pathwaysbiasbiological networkscancerdifferential gene expression

Identifiers

PMID33400606
PMCPMC8165462
OpenAlexW3119975365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.