Evidence map›Paper›PMID 33400168›Full record

SynthesisCurrent HIV/AIDS reports2021

Aging with HIV in Latin America and the Caribbean: a Systematic Review.

Diego M Cabrera, Monica M Diaz, Alyssa Grimshaw, Justina Salvatierra, Patricia J Garcia, Evelyn Hsieh

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Current HIV/AIDS reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  16. A Review of Chronic Comorbidities in People Living With HIV in Peru.Journal of the International Association of Providers of AIDS Care
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Diego M CabreraDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Monica M DiazEpidemiology, STD, and HIV Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Alyssa GrimshawHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT, USA.
Justina SalvatierraMedical Library, Universidad Peruana Cayetano Heredia, Lima, Peru.
Patricia J GarciaEpidemiology, STD, and HIV Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Evelyn HsiehSection of Rheumatology, Allergy and Immunology, Yale School of Medicine, 300 Cedar Street TAC S-525, PO Box 208031, New Haven, CT, 06520-8031, USA. evelyn.hsieh@yale.edu.
Universidad Peruana Cayetano Heredia · PEYale University · USUniversity of North Carolina at Chapel Hill · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Risk for Bone Loss Among Individuals with HIV in a Resource-Limited EnvironmentK01TW009995 · FIC · YALE UNIVERSITY · PI HSIEH, EVELYN · 2015 to 2019
$693k
FIC NIH HHS D43 TW009343FIC NIH HHS D43 TW010540FIC NIH HHS K01 TW009995NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

purpose of reviewWith the establishment of antiretroviral treatment (ART) programs in low- and middle-income countries, people with HIV (PWH) in Latin America and the Caribbean (LAC) are living longer, subsequently developing chronic non-communicable diseases (NCDs). Few studies focus on the impact of aging among older LAC PWH. This systematic review aims to fill this information gap and understand the burden of aging with HIV in LAC. We identified peer-reviewed literature published in English, Spanish, or Portuguese from several databases to assess currently available evidence on the burden of aging with HIV in LAC and selected six common NCDs found in older PWH (cardiovascular disease [CVD], bone and musculoskeletal [MSK] disorders, cancer, renal disease, neurocognitive impairment [NCI], and depression). RECENT

findingsOf the 5942 publications reviewed, only 53 articles were found with populations 40 years and older or age-related findings (27 CVD, 13 NCI or depression, 6 MSK disorders, 4 renal disease, 3 cancer). Most (79%) publications were from Brazil with few longitudinal studies on aging with HIV. Prevalence of illnesses such as CVD, NCI, depression, or osteoporosis varied widely depending on the screening instrument utilized and geographic population surveyed. Age was a significant predictor of comorbidity in nearly all studies. Our results demonstrate the need for longitudinal studies and validated screening instruments appropriate for use among PWH in LAC. Understanding the mechanisms behind aging in HIV and the roles of sociocultural factors and genetic diversity specific to LAC is needed to appropriately manage chronic comorbidities as PWH age.

Indexed as

HIV InfectionsAgedAgingBrazilCaribbean RegionHumansLatin AmericaAgingHIVLatin AmericaMorbidityThe Caribbean

Identifiers

PMID33400168
PMCPMC8059362
OpenAlexW3120936756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.