Evidence map›Paper›PMID 33400134›Full record

ArticleIndian journal of pediatrics2021

UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy.

P B Nandith, Usha Adiga, Vijaya Shenoy, Sachidananda Adiga M N

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Article in Indian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023
    Review
  4. Article
  5. Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

P B NandithResearch Scholar, K S Hegde Medical Academy, Nitte (Deemed to be University), Derlakatte, Mangalore, Karnataka, India.
Usha AdigaDepartment of Pharmacology, Pediatrics & Biochemistry, K S Hegde Medical Academy, Nitte (Deemed to be University), Derlakatte, Mangalore, Karnataka, India.
Vijaya ShenoyDepartment of Pharmacology, Pediatrics & Biochemistry, K S Hegde Medical Academy, Nitte (Deemed to be University), Derlakatte, Mangalore, Karnataka, India.
Sachidananda Adiga M NDepartment of Pharmacology, Pediatrics & Biochemistry, K S Hegde Medical Academy, Nitte (Deemed to be University), Derlakatte, Mangalore, Karnataka, India. adigapharma@nitte.edu.in.
K S Hegde Medical Academy · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients and to compare the sodium valproate concentration in different patterns of UGT gene polymorphism.

methodsIn this cross-sectional study, 99 pediatric epileptic patients aged 2-18 y receiving Sodium valproate monotherapy for the past one month were included from JusticeK S Hegde Charitable hospital, Mangalore after obtaining informed consent. Genetic polymorphism patterns were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Trough level serum valproate concentration was estimated by high-performance liquid chromatography (HPLC). Sodium valproate concentration in different UGT genotypes was compared by Analysis of Variance (ANOVA). P value <0.05 was considered significant.

resultsIn the present study population, the predominant mutant allele pattern was observed in UGT1A6 (T19G, A541G, A552C) gene. In UGT2B7 (A268G, C161T) showed predominant mutant allele pattern while (G211T) showed predominant wild type. Mean steady-state sodium valproate concentration was 105.40 ± 49.9 μg/ml and adjusted sodium valproate concentration was 5.5 ± 3.2 mg/kg/L. It was found that there was no statistical difference in sodium valproate concentration in different UGT1A6 and UGT2B7 gene polymorphism.

conclusionThe present study concluded that though there was a difference in pattern of gene polymorphism with concerning UGT1A6 and UGT2B7, however, it has not contributed to variation in serum concentration of sodium valproate in the present study population.

Indexed as

AnticonvulsantsValproic AcidChildCross-Sectional StudiesGlucuronosyltransferaseHumansPolymorphism, Single NucleotideAnticonvulsantsGlucuronosyltransferaseUDP-glucuronosyltransferase, UGT1A6UGT2B7 protein, humanValproic AcidGenetic polymorphismPediatric epilepsySodium valproate

Identifiers

PMID33400134
OpenAlexW3120956602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.