Evidence map›Paper›PMID 33400044›Full record

SynthesisArchives of osteoporosis2021

Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis.

Fulong Zhao, Lijuan Guo, Xuefei Wang, Yakui Zhang

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of osteoporosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06866561 (The Effect of Aerobic Exercise on Bone Formation and Resorption Markers And The Quality of Life Tests in Postmenopausal Osteopenic Patients), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06866561 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Aerobic Exercise on Bone Formation and Resorption Markers And The Quality of Life Tests in Postmenopausal Osteopenic Patients

TypeinterventionalSponsorBursa Yuksek Ihtisas Training and Research HospitalRan2022 to 2023Enrolled45ConditionsPostmenopausal OsteopeniaArmsaerobic exercise, cholecalciferol, calcium carbonate
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Nrf2 signaling pathway: focus on oxidative stress in osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. The Potential of Superoxide Dismutase-RichInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fulong Zhao *Department of Trauma Orthopedics, Beijing Luhe Hospital affiliated to Capital Medical University, No.82 Xinhua South road, Tongzhou District, Beijing, 101149, China.
Lijuan Guo *Clinical laboratory, Emergency General Hospital, Beijing, 100028, China.
Xuefei WangDepartment of Trauma Orthopedics, Beijing Luhe Hospital affiliated to Capital Medical University, No.82 Xinhua South road, Tongzhou District, Beijing, 101149, China. xuefeiwang123@sina.com.
Yakui ZhangDepartment of Trauma Orthopedics, Beijing Luhe Hospital affiliated to Capital Medical University, No.82 Xinhua South road, Tongzhou District, Beijing, 101149, China.
Beijing Luhe Hospital Affiliated to Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress (OS) is implicated in postmenopausal osteoporosis (PO). Results show an imbalance between antioxidative and oxidative markers in PO. Thus, monitoring of OS-related biomarkers and keeping balance between reactive oxygen species and antioxidant system are beneficial to the diagnosis and prognosis of PO. PURPOSE: Oxidative stress (OS) has been implicated in postmenopausal osteoporosis (PO). However, the relations between OS-related markers and PO are controversial. This study aimed to quantitatively and comprehensively assess the roles of OS-related biomarkers in PO.

methodsRelevant articles were retrieved from electronic databases. All OS-associated biomarkers with at least 2 independent study outcomes were meta-analyzed. The pooled standardized mean differences (SMD) with its 95% confidence intervals (CI) were presented.

resultsA total of 36 studies involving 16 OS-related biomarkers were investigated. The overall results showed that total oxidant status (TOS), superoxide dismutase (SOD), hydroperoxides (HY), paraoxonase (PON1), nitric oxide (NO), and homocysteine (Hcy) were not statistically different between the PO and control groups, whereas significantly increased levels of oxidative stress index (OSI), malondialdehyde (MDA), advanced oxidation protein products (AOPP), and vitamin B12, along with decreased total antioxidant status (TAS), total antioxidant power (TAP), catalase (CAT), glutathione peroxidase (GPx), uric acid (UA), and folate, were detected in the PO group. Subgroup analysis based on biological samples displayed significantly elevated NO in erythrocyte and Hcy in serum, along with decreased SOD in serum.

conclusionMonitoring of certain OS-related biomarkers might be beneficial to the diagnosis and prognosis of PO.

Indexed as

Osteoporosis, PostmenopausalAntioxidantsAryldialkylphosphataseBiomarkersFemaleHumansMalondialdehydeOxidative StressAntioxidantsAryldialkylphosphataseBiomarkersMalondialdehydePON1 protein, humanAntioxidantBone mineral densityOxidative stressPostmenopausal osteoporosis

Identifiers

PMID33400044
OpenAlexW3120966696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.