ArticleMetabolomics : Official journal of the Metabolomic Society2021
Metabolomics by UHPLC-HRMS reveals the impact of heat stress on pathogen-elicited immunity in maize.
Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Seed metabolomic profiling of contrasting mung bean (Vigna radiata) genotypes under heat stress.Scientific reports · 2026Article
- When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms.Plant, cell & environment · 2026Review
- Systems Biology Applications in Revealing Plant Defense Mechanisms in Disease Triangle.International journal of molecular sciences · 2025Review
- OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice.Nature communications · 2025Article
- Article
- A generic part of specific combined responses to biotic and abiotic stresses in crops: Overcoming multifaceted challenges towards new opportunities.Frontiers in plant science · 2023Article
- A comprehensive dynamic immune acetylproteomics profiling induced by Puccinia polysora in maize.BMC plant biology · 2022Article
- Liguleless narrow and narrow odd dwarf act in overlapping pathways to regulate maize development and metabolism.The Plant journal : for cell and molecular biology · 2022Article
- Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology.International journal of molecular sciences · 2022Review
- RNAi-induced knockdown of white gene in the southern green stink bug (Nezara viridula L.).Scientific reports · 2022Article
- Negative Effects of Rhizobacteria Association on Plant Recruitment of Generalist Predators.Plants (Basel, Switzerland) · 2022Article
- Unravelling Plant Responses to Stress-The Importance of Targeted and Untargeted Metabolomics.Metabolites · 2021Review
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStudies investigating crop resistance to abiotic and biotic stress have largely focused on plant responses to singular forms of stress and individual biochemical pathways that only partially represent stress responses. Thus, combined abiotic and biotic stress treatments and the global assessment of their elicited metabolic expression remains largely unexplored. In this study, we employed targeted and untargeted metabolomics to investigate the molecular responses of maize (Zea mays) to abiotic, biotic, and combinatorial stress.
objectiveWe compared the inducible metabolomes of heat-stressed (abiotic) and C. heterostrophus-infected (biotic) maize and examined the effects of heat stress on the ability of maize to defend itself against C. heterostrophus.
methodsUltra-high-performance liquid chromatography-high-resolution mass spectrometry was performed on plants grown under control conditions (28 °C), heat stress (38 °C), Cochliobolus heterostrophus infection, or combinatorial stress [heat (38 °C) + C. heterostrophus infection].
resultsMultivariate analyses revealed differential metabolite expression between heat stress, C. heterostrophus infection, and their respective controls. In combinatorial experiments, treatment with heat stress prior to fungal inoculation negatively impacted maize disease resistance against C. heterostrophus, and distinct metabolome separation between combinatorial stressed plants and the non-heat-stressed infected controls was observed. Targeted analysis revealed inducible primary and secondary metabolite responses to abiotic/biotic stress, and combinatorial experiments indicated that deficiency in the hydroxycinnamic acid, p-coumaric acid, may contribute to the heat-induced susceptibility of maize to C. heterostrophus.
conclusionThese findings demonstrate that abiotic stress can predispose crops to more severe disease symptoms, underlining the increasing need to investigate defense chemistry in plants under combinatorial stress.
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