ArticleEuropean journal of nutrition2021
Fruit intake, genetic risk and type 2 diabetes: a population-based gene-diet interaction analysis.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Both Isocarbohydrate and Hypercarbohydrate Fruit Preloads Curbed Postprandial Glycemic Excursion in Healthy Subjects.Nutrients · 2021Trial
- Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case-cohort study.The American journal of clinical nutrition · 2026Article
- Personalized Nutrition in the Era of Digital Health: A New Frontier for Managing Diabetes and Obesity.Food science & nutrition · 2025Review
- Changes in food choices and dietary patterns during the lifestyle intervention and their association with type 2 diabetes risk in participants with high or low genetic risk for type 2 diabetes.European journal of nutrition · 2025Article
- Interaction between coffee consumption and polygenic risk score in relation to diabetes: insights from the Maastricht study.European journal of nutrition · 2025Article
- Diet-Gene Interaction Between Fruit Intake andNutrients · 2025Article
- Association Between the EAT-Lancet Reference Diet and Gestational Diabetes Mellitus: A Mini-Review.Nutrients · 2024Review
- Healthy dietary pattern is associated with lower glycemia independently of the genetic risk of type 2 diabetes: a cross-sectional study in Finnish men.European journal of nutrition · 2024Article
- Fresh fruit, dried fruit, raw vegetables, and cooked vegetables consumption associated with progression trajectory of type 2 diabetes: a multi-state analysis of a prospective cohort.European journal of nutrition · 2024Article
- Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus.World journal of diabetes · 2024Review
- A low-inflammatory diet is associated with a lower incidence of diabetes: role of diabetes-related genetic risk.BMC medicine · 2023Article
- Whole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation.European journal of nutrition · 2023Article
- Genome-Wide Interaction Study of Late-Onset Asthma With Seven Environmental Factors Using a Structured Linear Mixed Model in Europeans.Frontiers in genetics · 2022Article
- Article
- Insulin-Mimic Components inPharmaceuticals (Basel, Switzerland) · 2021Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
purposeWhether the association between fruit and type 2 diabetes (T2D) is modified by the genetic predisposition of T2D was yet elucidated. The current study is meant to examine the gene-dietary fruit intake interactions in the risk of T2D and related glycemic traits.
methodsWe performed a cross-sectional study in 11,657 participants aged ≥ 40 years from a community-based population in Shanghai, China. Fruit intake information was collected by a validated food frequency questionnaire by asking the frequency of consumption of typical food items over the previous 12 months. T2D-genetic risk score (GRS) was constructed by 34 well established T2D common variants in East Asians. The risk of T2D, fasting, 2 h-postprandial plasma glucose, and glycated hemoglobin A1c associated with T2D-GRS and each individual single nucleotide polymorphisms (SNPs) were tested.
resultsThe risk of T2D associated with each 1-point of T2D-GRS was gradually decreased from the lower fruit intake level (< 1 times/week) [the odds ratio (OR) and 95% confidence interval (CI) was 1.10 (1.07-1.13)], to higher levels (1-3 and > 3 times/week) [the corresponding ORs and 95% CIs were 1.08 (1.05-1.10) and 1.07 (1.05-1.08); P for interaction = 0.04]. Analyses for associations with fasting, 2 h-postprandial plasma glucose and glycated hemoglobin A1c demonstrated consistent tendencies (all P for interaction ≤ 0.03). The inverse associations of fruit intake with risk of T2D and glucose traits were more prominent in the higher T2D-GRS tertile.
conclusionsFruit intakes interact with the genetic predisposition of T2D on the risk of diabetes and related glucose metabolic traits. Fruit intake alleviates the association between genetic predisposition of T2D and the risk of diabetes; the association of fruit intake with a lower risk of diabetes was more prominent in population with a stronger genetic predisposition of T2D.
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