Evidence map›Paper›PMID 33399973›Full record

ReviewEuropean journal of nutrition2021

Neurobiology of zinc and its role in neurogenesis.

Vijay Kumar, Ashok Kumar, Kritanjali Singh, Kapil Avasthi, Jong-Joo Kim

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  10. An emerging role for synaptic ZnPharmacology & therapeutics · 2026
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  11. The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Vijay Kumar *Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. vijaykumarcbt@gmail.com.ORCID http://orcid.org/0000-0002-8035-9181
Ashok Kumar *Department of Genetics, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, 226014, UP, India.
Kritanjali Singh *Central Research Station, Subharti Medical College, Swami Vivekanand Subharti University, Meerut, 250002, India.
Kapil AvasthiDepartment of Genetics, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, 226014, UP, India.
Jong-Joo KimDepartment of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. kimjj@ynu.ac.kr.
Sanjay Gandhi Post Graduate Institute of Medical Sciences · INYeungnam University · KRSwami Vivekanand Subharti University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundZinc (Zn) has a diverse role in many biological processes, such as growth, immunity, anti-oxidation system, homeostatic, and repairing. It acts as a regulatory and structural catalyst ion for activities of various proteins, enzymes, and signal transcription factors, as well as cell proliferation, differentiation, and survival. The Zn ion is essential for neuronal signaling and is mainly distributed within presynaptic vesicles. Zn modulates neuronal plasticity and synaptic activity in both neonatal and adult stages. Alterations in brain Zn status results in a dozen neurological diseases including impaired brain development. Numerous researchers are working on neurogenesis, however, there is a paucity of knowledge about neurogenesis, especially in neurogenesis in adults. Neurogenesis is a multifactorial process and is regulated by many metal ions (e.g. Fe, Cu, Zn, etc.). Among them, Zn has an essential role in neurogenesis. At the molecular level, Zn controls cell cycle, apoptosis, and binding of DNA and several proteins including transcriptional and translational factors. Zn is needed for protein folding and function and Zn acts as an anti-apoptotic agent; organelle stabilizer; and an anti-inflammatory agent. Zn deficiency results in aging, neurodegenerative disease, immune deficiency, abnormal growth, cancer, and other symptoms. Prenatal deficiency of Zn results in developmental disorders in humans and animals.

conclusionBoth in vitro and in vivo studies have shown an association between Zn deficiency and increased risk of neurological disorders. This article reviews the existing knowledge on the role of Zn and its importance in neurogenesis.

Indexed as

Neurodegenerative DiseasesZincAnimalsApoptosisFemaleHumansInfant, NewbornNeurogenesisNeuronsPregnancyZincNeurogenesisNeuronal differentiationNeuronal precursor survivalNeurotransmissionStem cell proliferationZinc

Identifiers

PMID33399973
OpenAlexW3120935767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.