Evidence map›Paper›PMID 33399910›Full record

ArticleDiabetologia2021

A prospective study of endometriosis and risk of type 2 diabetes.

Leslie V Farland, William J Degnan, Holly R Harris, Deirdre K Tobias, Stacey A Missmer

Open access · bronzeAbstract read
In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. The interplay between endometriosis and obesity.Trends in endocrinology and metabolism: TEM · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Endometriosis and cardiovascular disease.European heart journal open · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Leslie V FarlandDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA. lfarland@email.arizona.edu.ORCID 0000-0001-7455-8531
William J DegnanDepartment of Community, Environment, and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-7286-9790
Holly R HarrisEpidemiology, Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-2572-6727
Deirdre K TobiasDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-0020-9552
Stacey A MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-3147-6768
University of Arizona · USBrigham and Women's Hospital · USHarvard University · USUniversity of Washington · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI Xinxin Ding · 1994 to 2026
$36.7M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Immunology, Inflammation, and EndometriosisR01HD057210 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI MISSMER, STACEY ANN · 2009 to 2012
$1.4M
PCOS, Type II diabetes and ovarian cancer riskK22CA193860 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HARRIS, HOLLY RUTH · 2016 to 2018
$554k
NCI NIH HHS K22 CA193860NCI NIH HHS U01 CA176726NICHD NIH HHS R01 HD057210NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

aims/hypothesisThe objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes.

methodsWe used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazards models to estimate the HRs and 95% CIs of incident, confirmed type 2 diabetes (n = 8496 participants) adjusted a priori for confounding factors. We additionally investigated differences in the relationship between endometriosis and type 2 diabetes by age (<50 or ≥50 years), BMI (<30 or ≥30 kg/m

resultsWe saw no association between laparoscopically confirmed endometriosis and risk of type 2 diabetes in multivariable confounder-adjusted models (HR 1.06 [95% CI 0.98, 1.13]) or models accounting for potential mediating factors (HR 0.94 [95% CI 0.87, 1.00]). However, we observed modest differences in the association between endometriosis and type 2 diabetes by BMI group, history of infertility and history of GDM. Among non-obese women (HR 1.17 [95% CI 1.02, 1.35]), women who never experienced infertility (HR 1.14 [95% CI 1.04, 1.25]) and women who never experienced GDM (HR 1.11 [95% CI 1.01, 1.22]), endometriosis was associated with greater risk of type 2 diabetes. CONCLUSIONS/

interpretationOverall, women with endometriosis were not at increased risk of type 2 diabetes. However, among subgroups at low risk for type 2 diabetes (i.e. non-obese women and women with no prior history of infertility or GDM), endometriosis was associated with a modest increased risk of type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 2EndometriosisFemaleHumansLongitudinal StudiesMiddle AgedNursesPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsUnited StatesDiabetesEndometriosisEpidemiologyGestational diabetes

Identifiers

PMID33399910
PMCPMC8609862
OpenAlexW3121022203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.