Evidence map›Paper›PMID 33399885›Full record

SynthesisSocial psychiatry and psychiatric epidemiology2021

The association between migrant status and transition in an ultra-high risk for psychosis population.

Brian O'Donoghue, Hellen Geros, Holly Sizer, Jean Addington, G Paul Amminger, Carrie E Beaden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Gregor Emanuel Berger and 31 more

Open access · greenAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Social psychiatry and psychiatric epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 11 countries.

Brian O'DonoghueOrygen, Melbourne, Australia. brian.odonoghue@orygen.org.au.ORCID http://orcid.org/0000-0001-6240-6952
Hellen GerosOrygen, Melbourne, Australia.
Holly SizerOrygen, Melbourne, Australia.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
G Paul AmmingerOrygen, Melbourne, Australia.
Carrie E BeadenDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Kristin S CadenheadDepartment of Psychiatry, UCSD, San Diego, CA, USA.
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, CT, USA.
Barbara A CornblattDepartment of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA.
Gregor Emanuel BergerChild and Adolescent Psychiatric Service of the Canton of Zurich, Zürich, Switzerland.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
Lieuwe de HaanDepartment of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Jessica A HartmannOrygen, Melbourne, Australia.
Ian B HickieBrain and Mind Research Institute, University of Sydney, Sydney, Australia.
Helga K IsingDepartment of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands.
Suzie LavoieOrygen, Melbourne, Australia.
Ashleigh LinTelethon Kids Institute, Perth, Australia.
Connie MarkulevOrygen, Melbourne, Australia.
Daniel H MathalonDepartment of Psychiatry, UCSF, San Francisco, CA, USA.
Thomas H McGlashanDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Nathan G MifsudOrygen, Melbourne, Australia.
Nilufar MossahebDepartment of Psychiatry, Medical University of Vienna, Vienna, Austria.
Dorien H NiemanDepartment of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Merete NordentoftPsychiatric Centre Bispebjerg, Copenhagen, Denmark.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Anita Riecher-RösslerPsychiatric University Clinics Basel, Basel, Switzerland.
Miriam R SchäferOrygen, Melbourne, Australia.
Monika SchlögelhoferDepartment of Psychiatry, Medical University of Vienna, Vienna, Austria.
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
Stephan SmesnyDepartment of Psychiatry, University Hospital Jena, Jena, Germany.
Andrew ThompsonOrygen, Melbourne, Australia.
Ming T TsuangDepartment of Psychiatry, UCSD, San Diego, CA, USA.
Mark van der GaagDepartment of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands.
Swapna VermaInstitute of Mental Health, Singapore, Singapore.
Elaine F WalkerDepartment of Psychology, Emory University, Atlanta, GA, USA.
Stephen J WoodOrygen, Melbourne, Australia.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Hok Pan YuenOrygen, Melbourne, Australia.
Alison Ruth YungOrygen, Melbourne, Australia.
Patrick D McGorryOrygen, Melbourne, Australia.
Barnaby NelsonOrygen, Melbourne, Australia.
The University of Melbourne · AUYale University · USAmsterdam UMC Location University of Amsterdam · NLMedical University of Vienna · ATParnassia Groep · NLUniversity of California San Diego · USBeth Israel Deaconess Medical Center · USBispebjerg Hospital · DKEmory University · USInstitute of Mental Health · SGJena University Hospital · DENeurobehavioral Systems · USSan Francisco VA Medical Center · USThe Kids Research Institute Australia · AUThe University of Sydney · AUUniversitäre Psychiatrische Kliniken Basel · CHUniversity of Calgary · CAUniversity of Hong Kong · HKUniversity of North Carolina at Chapel Hill · USZucker Hillside Hospital · US

Funding

5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Enhancing the Prospective Prediction of PsychosisU01MH066069 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2003 to 2007
$1.5M
NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH082004
6 · The paper itself

Abstract

purposeMigrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.

methodsHazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model.

results2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147-756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62-1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70-1.51).

conclusionsThis meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.

Indexed as

Psychotic DisordersTransients and MigrantsAdolescentAdultCohort StudiesHumansProportional Hazards ModelsPsychiatric Status Rating ScalesRisk FactorsYoung AdultMigrantsPsychotic disordersUltra-high risk for psychosis

Identifiers

PMID33399885
OpenAlexW3119224136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.