Evidence map›Paper›PMID 33399609›Full record

ArticleOrganic & biomolecular chemistry2021

Intramolecular N-Me and N-H aminoetherification for the synthesis of

Mahesh P Paudyal, Mingliang Wang, Juha H Siitonen, Yimin Hu, Muhammed Yousufuddin, Hong C Shen, John R Falck, László Kürti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahesh P PaudyalDivision of Chemistry, Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. j.falck@utsouthwestern.edu.
Mingliang WangDepartment of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, P. R. China.
Juha H SiitonenDepartment of Chemistry, Rice University, 6500 Main Street, Houston, Texas 77030, USA. lk18@rice.edu.ORCID 0000-0002-9816-637X
Yimin HuRoche Pharma Research & Early Development, Roche Innovation Center Shanghai, Roche R&D Center (China) Ltd, Building 5, No. 371, Lishizhen Road, Shanghai 201203, P. R. China. hong.shen.hs1@roche.com.
Muhammed YousufuddinLife and Health Sciences Department, The University of North Texas at Dallas, 7400 University Hills Boulevard, Dallas, TX 75241, USA.
Hong C ShenRoche Pharma Research & Early Development, Roche Innovation Center Shanghai, Roche R&D Center (China) Ltd, Building 5, No. 371, Lishizhen Road, Shanghai 201203, P. R. China. hong.shen.hs1@roche.com.
John R FalckDivision of Chemistry, Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. j.falck@utsouthwestern.edu.ORCID 0000-0002-9219-7845
László KürtiDepartment of Chemistry, Rice University, 6500 Main Street, Houston, Texas 77030, USA. lk18@rice.edu.ORCID 0000-0002-3412-5894

Funding

Molecular Mechanisms of 20-HETE-mediated Vascular Dysfunction and HypertensionR01HL139793 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SCHWARTZMAN, MICHAL LANIADO · 2018 to 2021
$2.7M
New catalytic methods for the rapid synthesis of N-unprotected chiral aziridines and aminesR35GM136373 · NIGMS · RICE UNIVERSITY · PI KURTI, LASZLO · 2020 to 2024
$2.1M
NHLBI NIH HHS R01 HL139793NIGMS NIH HHS R35 GM136373
6 · The paper itself

Abstract

A mild Rh-catalyzed method for synthesis of cyclic unprotected N-Me and N-H 2,3-aminoethers using an olefin aziridination-aziridine ring-opening domino reaction has been developed. The method is readily applicable to the stereocontrolled synthesis of a variety of 2,3-disubstituted aminoether O-heterocyclic scaffolds, including tetrahydrofurans, tetrahydropyrans and chromanes.

Indexed as

Chemistry Techniques, SyntheticEthersHeterocyclic CompoundsHydrogenNitrogenStereoisomerismEthersHeterocyclic CompoundsHydrogenNitrogen

Identifiers

PMID33399609
PMCPMC8183519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.