Evidence map›Paper›PMID 33399536›Full record

ArticleeLife2021

Ca

Salah A Baker, Wesley A Leigh, Guillermo Del Valle, Inigo F De Yturriaga, Sean M Ward, Caroline A Cobine, Bernard T Drumm, Kenton M Sanders

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. CaPhysiological reviews · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. CaThe Journal of physiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salah A BakerDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.ORCID 0000-0002-1514-6876
Wesley A LeighDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Guillermo Del ValleDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Inigo F De YturriagaDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Caroline A CobineDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Bernard T DrummDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, United States.

Funding

Tissue, Cell and Tissue Culture CoreP01DK041315 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 1989 to 2018
$26.3M
Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Control of motility in the internal anal sphincterR01DK078736 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 2010 to 2019
$3.4M
Role of interstitial cells of Cajal in patterned colonic motor activityR01DK120759 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Sal Baker, KENTON M SANDERS · 2019 to 2026
$3.4M
NIDDK NIH HHS P01 DK041315NIDDK NIH HHS R01 DK078736NIDDK NIH HHS R01 DK120759NIGMS NIH HHS P30 GM110767
6 · The paper itself

Abstract

Interstitial cells of Cajal (ICC) generate pacemaker activity responsible for phasic contractions in colonic segmentation and peristalsis. ICC along the submucosal border (ICC-SM) contribute to mixing and more complex patterns of colonic motility. We show the complex patterns of Ca

Indexed as

Biological ClocksCalcium SignalingAnimalsColonInterstitial Cells of CajalMiceMyocytes, Smooth Muscleca2+ entryca2+-induced ca2+ releaseca2+ signalingcell biologygi motilitymolecular biophysicsmousepacemakerslow wavesstructural biology

Identifiers

PMID33399536
PMCPMC7806270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.