Evidence map›Paper›PMID 33398664›Full record

ReviewMolecular and cellular biochemistry2021

Contribution of RAGE axis activation to the association between metabolic syndrome and cancer.

Ma Eugenia Garay-Sevilla, Armando Gomez-Ojeda, Ileana González, Claudia Luévano-Contreras, Armando Rojas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ma Eugenia Garay-SevillaDepartment of Medical Science, Division of Health Science, University of Guanajuato, Campus León, Guanajuato, Mexico.
Armando Gomez-OjedaDepartment of Medical Science, Division of Health Science, University of Guanajuato, Campus León, Guanajuato, Mexico.
Ileana GonzálezBiomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
Claudia Luévano-ContrerasDepartment of Medical Science, Division of Health Science, University of Guanajuato, Campus León, Guanajuato, Mexico.
Armando RojasBiomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile. arojasr@ucm.cl.ORCID http://orcid.org/0000-0001-9911-7142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different types of cancer. However, the involved molecular mechanisms underlying this association are not fully understood, and they have been mainly focused on the individual contributions of each component of the metabolic syndrome such as obesity, hyperglycemia, and high blood pressure to the development of cancer. The Receptor for Advanced Glycation End-products (RAGE) axis activation has emerged as an important contributor to the pathophysiology of many clinical entities, by fueling a chronic inflammatory milieu, and thus supporting an optimal microenvironment to promote tumor growth and progression. In the present review, we intend to highlight that RAGE axis activation is a crosswise element on the potential mechanistic contributions of some relevant components of metabolic syndrome into the association with cancer.

Indexed as

Gene Expression RegulationAdiponectinAdipose TissueAnimalsDisease ProgressionHumansHyperglycemiaHypertensionInflammationInsulin-Like Growth Factor ILeptinLigandsMetabolic SyndromeMiceNeoplasmsObesityAdiponectinAGER protein, humanInsulin-Like Growth Factor ILeptinLigandsPeroxisome Proliferator-Activated ReceptorsReceptor for Advanced Glycation End ProductsVascular Endothelial Growth Factor AWnt ProteinsAdipose tissueAdvanced glycation end-productsAlarminsCancerInflammationMetabolic syndromeObesity

Identifiers

PMID33398664

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.