ArticleBiological trace element research2021
The Alleviative Effects of Quercetin on Cadmium-Induced Necroptosis via Inhibition ROS/iNOS/NF-κB Pathway in the Chicken Brain.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nutritional nanotherapy with quercetin-loaded chitosan nanoparticles ameliorates imidacloprid-induced liver toxicity through antioxidant, anti-Inflammatory, and genoprotective mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Nutraceuticals: A strategy to mitigate neurotoxicity.Advances in neurotoxicology · 2026Article
- Protective effect of L-carnitine on cadmium induced neurotoxicity in rats.Toxicology research · 2025Article
- Unlocking the Neuroprotective Effect of Quercetin Against Cadmium-Induced Hippocampal Damage in Rats: PPARγ Activation as a Key Mechanism.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Interactions Between Ferroptosis and Oxidative Stress in Ischemic Stroke.Antioxidants (Basel, Switzerland) · 2024Review
- Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential.Current drug targets · 2024Review
- Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis.Molecules (Basel, Switzerland) · 2023Article
- Quercetin Ameliorates Deoxynivalenol-Induced Intestinal Injury and Barrier Dysfunction Associated with Inhibiting Necroptosis Signaling Pathway in Weaned Pigs.International journal of molecular sciences · 2023Article
- The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation.Antioxidants (Basel, Switzerland) · 2023Article
- Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways.Journal of animal science and biotechnology · 2023Article
- Heat Shock Protein Response to Stress in Poultry: A Review.Animals : an open access journal from MDPI · 2023Review
- Review
- The effects of differential feeding on ileum development, digestive ability and health status of newborn calves.Frontiers in veterinary science · 2023Article
- Protective Effects of Astilbin Against Cadmium-Induced Apoptosis in Chicken Kidneys via Endoplasmic Reticulum Stress Signaling Pathway.Biological trace element research · 2022Article
- Involvement of calcium homeostasis and unfolded protein response in autophagy co-induced by molybdenum and cadmium in duck (Anas platyrhyncha) brain.Environmental science and pollution research international · 2022Article
- Comparative and evolutionary analysis ofFrontiers in genetics · 2022Article
- Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation.Molecular medicine reports · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cadmium (Cd), a ubiquitous environmental pollutant, has neurotoxicity to humans and animals. Quercetin (QE), the main component of flavonoids, has strong antioxidant and anti-inflammatory effects. However, little is reported about the influence of Cd exposure on necroptosis in the chicken brain and the antagonistic impacts of QE against Cd-induced brain necroptosis. The aim of this study was to ascertain the alleviative mechanism of QE on Cd-induced necroptosis in the chicken brain. Two hundred 3.5-month-old Isa hens were randomly divided into four groups, control group, QE group, Cd group, and Cd + QE co-administration group. The histopathological analysis indicated that necrosis features were observed in the Cd-intoxicated chicken brains. Meanwhile, the expression levels of RIPK1, RIPK3, and MLKL were elevated and the level of Caspase 8 was reduced in the Cd group, which further testified Cd triggered the occurrence of necroptosis in the chicken brain. Cd exposure obviously increased Cd accumulation, ROS generation, and MDA level; weakened the activities of antioxidase (SOD, GPx, and CAT); enhanced iNOS activity and NO production; promoted the expression of inflammatory factors (NF-κB, TNFα, COX-2, iNOS, PTGEs, and IL-1β); and activated HSPs (HSP27, HSP40, HSP60, HSP70, and HSP90). But, these Cd-caused variations were obviously attenuated in the Cd + QE group. This study indicated that QE had an alleviative effect on Cd-induced necroptosis in the chicken brain through inhibition ROS/iNOS/NF-κB pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.