Evidence map›Paper›PMID 33398572›Full record

ArticleSurgical endoscopy2021

POEM: clinical outcomes beyond 5 years.

Sarah C McKay, Christy M Dunst, Ahmed M Sharata, Reid Fletcher, Kevin M Reavis, Daniel Davila Bradley, Steven R DeMeester, Dolores Müller, Brett Parker, Lee L Swanström

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  3. Peroral endoscopic myotomyWorld journal of gastroenterology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sarah C McKayFoundation for Surgical Innovation and Education, Portland, OR, USA.
Christy M DunstFoundation for Surgical Innovation and Education, Portland, OR, USA. cdunst@orclinic.com.ORCID 0000-0002-8320-5428
Ahmed M SharataFoundation for Surgical Innovation and Education, Portland, OR, USA.
Reid FletcherFoundation for Surgical Innovation and Education, Portland, OR, USA.
Kevin M ReavisFoundation for Surgical Innovation and Education, Portland, OR, USA.
Daniel Davila BradleyFoundation for Surgical Innovation and Education, Portland, OR, USA.
Steven R DeMeesterFoundation for Surgical Innovation and Education, Portland, OR, USA.
Dolores MüllerFoundation for Surgical Innovation and Education, Portland, OR, USA.
Brett ParkerFoundation for Surgical Innovation and Education, Portland, OR, USA.
Lee L SwanströmFoundation for Surgical Innovation and Education, Portland, OR, USA.
Providence Portland Medical Center · USInstitute for Learning Innovation · USOregon Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe short-term success of peroral endoscopic myotomy (POEM) is well documented but the durability of the operation is questioned. The aim of this study was to evaluate the clinical outcomes of the POEM procedure for esophageal motility disorders in a large cohort in which all patients had at least 5 years of follow-up.

methodsAll patients from a single center who underwent a POEM between October 2010 and September 2014 were followed for long-term clinical outcomes. Postoperative Eckardt symptom scores of short term and ≥ 5 years were collected through phone interview. Clinical success was defined as an Eckardt score < 3. Overall success was defined as Eckardt score < 3 and freedom from additional interventions.

resultsOf 138 patients, 100 patients were available for follow-up (mean age 56, 52% male). The indication for operation was achalasia in 94. The mean follow-up duration was 75 months (range: 60-106 months). Dysphagia was improved in 91% of patients. Long-term overall success was achieved in 79% of patients (80% of achalasia patients, 67% of DES patients). Preoperative mean Eckardt score was 6. At 6 months, it was 1, and at 75 months, it was 2 (p = 0.204). Five-year freedom from intervention was 96%. Overall, 7 patients had additional treatments: 1 balloon dilation (35 mm), 4 laparoscopic Heller myotomy, and 2 redo POEM at a mean of 51 months post-POEM. Ninety-three percent expressed complete satisfaction with POEM.

conclusionA multitude of studies has shown the early benefits of POEM. Here, we show that nearly 80% of patients report clinical success with no significant decrement in symptom scores between their short- and long-term follow-up. Clearly POEM is an effective option for achalasia with durable long-term treatment efficacy.

Indexed as

Deglutition DisordersEsophageal AchalasiaEsophageal Motility DisordersHeller MyotomyNatural Orifice Endoscopic SurgeryEsophageal Sphincter, LowerFemaleHumansMaleMiddle AgedTreatment OutcomeAchalasiaEndoscopic myotomyEndoscopic surgeryEsophageal myotomyLong-term outcomesPOEM

Identifiers

PMID33398572
OpenAlexW3120865561

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.