Evidence map›Paper›PMID 33398527›Full record

ArticleAmino acids2021

Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer.

Merve Celik Tekeli, Yesim Aktas, Nevin Celebi

Abstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Merve Celik TekeliDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey.
Yesim AktasDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Erciyes University, 38238, Kayseri, Turkey.
Nevin CelebiDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey. ncelebi51@gmail.com.ORCID http://orcid.org/0000-0002-6402-5042

Funding

TUBİTAK 217S416
6 · The paper itself

Abstract

The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is commercially available only in subcutaneous form, several attempts have been made to discover an effective oral formulation. Self-nanoemulsifying drug delivery systems are known to be suitable carriers for the oral administration of peptide drugs. Various ratios of oil, surfactant, and co-surfactant mixtures were used to determine the area in the pseudoternary phase diagram for clear nanoemulsion. The Design of Experiment approach was used for the optimization of the formulation. Blank self-nanoemulsifying formulations containing ethyl oleate as oil phase, Cremophor EL

Indexed as

Caco-2 CellsCell SurvivalDrug Delivery SystemsDrug StabilityEmulsionsEthanolExenatideGlucagon-Like Peptide 1GlyceridesGlycerolHumansOleic AcidsPermeabilityPropylene GlycolsSurface-Active Agentscremophor ELEmulsionsEthanolethyl oleateExenatideGlucagon-Like Peptide 1GlyceridesGlycerolLabrasolOleic AcidsPropylene GlycolsSurface-Active AgentsCaco-2 permeabilityDesign of experimentExendin-4Peptide deliverySelf nanoemulsifying system

Identifiers

PMID33398527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.