Evidence map›Paper›PMID 33398432›Full record

ArticleBrain structure & function2021

Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.

Samir A Nacer, Ayland C Letsinger, Simone Otto, Jemma Strauss DeFilipp, Viktoriya D Nikolova, Natallia V Riddick, Korey D Stevanovic, Jesse D Cushman, Jerrel L Yakel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Samir A Nacer *Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Ayland C Letsinger *Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Simone OttoNeurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Jemma Strauss DeFilippNeurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Viktoriya D NikolovaUNC Affiliation: Mouse Behavioral Phenotyping Laboratory, Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, 27516, USA.
Natallia V RiddickUNC Affiliation: Mouse Behavioral Phenotyping Laboratory, Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, 27516, USA.
Korey D StevanovicNeurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Jesse D CushmanNeurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA.
Jerrel L YakelNeurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Mail Drop F2-08, P.O. Box 12233, Durham, NC, 27709, USA. yakel@niehs.nih.gov.ORCID http://orcid.org/0000-0001-5463-674X
National Institutes of Health · US

Funding

Modulation Of Neuronal Channels and Receptors in the BrainZIAES090089 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI YAKEL, JERREL L · 2009 to 2025
$42.2M
Neurobehavioral Core LaboratoryZICES103330 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUSHMAN, JESSE · 2018 to 2025
$13.3M
MODULATION OF NEURONAL LIGAND-GATED CHANNELS BY CALCIUM DEPENDENT MECHANISMSZ01ES090089 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI YAKEL, JERREL L · 1997 to 2008
$3.6M
Intramural NIH HHS Z01 ES090089Intramural NIH HHS ZIC ES103330
6 · The paper itself

Abstract

The dentate gyrus (DG) is a unique brain structure in that neurons can be generated postnatally and integrated within existing circuitry throughout life. The maturation process of these newly generated neurons (granule cells) is modulated by nicotinic acetylcholine receptors (nAChRs) through a variety of mechanisms such as neural stem pool proliferation, cell survival, signal modulation, and dendritic integration. Disrupted nAChR signaling has been implicated in neuropsychiatric and neurodegenerative disorders, potentially via alterations in DG neurogenesis. GABAergic interneurons are known to express nAChRs, predominantly the α7 subtype, and have been shown to shape development, integration, and circuit reorganization of DG granule cells. Therefore, we examined histological and behavioral effects of knocking out α7 nAChRs in GABAergic neurons. Deletion of α7 nAChRs resulted in a reduction of radial glia-like cells within the subgranular zone of the DG and a concomitant trend towards decreased immature neurons, specifically in male mice, as well as sex-dependent changes in several behaviors, including social recognition and spatial learning. Overall, these findings suggest α7 nAChRs expressed in GABAergic neurons play an important role in regulating the adult neural stem cell pool and behavior in a sex-dependent manner. This provides important insight into the mechanisms by which cholinergic dysfunction contributes to the cognitive and behavioral changes associated with neurodevelopmental and neurodegenerative disorders.

Indexed as

Social Behavioralpha7 Nicotinic Acetylcholine ReceptorAnimalsBehavior, AnimalCell CountCognitionDentate GyrusDoublecortin ProteinEpendymoglial CellsFemaleGABAergic NeuronsMaleMiceMice, KnockoutNeurogenesisSex Factorsalpha7 Nicotinic Acetylcholine ReceptorDcx protein, mouseDoublecortin ProteinDCXGFAPMemoryNeurogenesisProgenitorStem cell

Identifiers

PMID33398432
PMCPMC8121181
OpenAlexW3120461269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.