ArticleBrain structure & function2021
Task-specific modulation of PFC activity for matching-rule governed decision-making.
Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.Communications biology · 2025Article
- Enhancing golf swing performance through M1-targeted transcranial direct current stimulation: a double-blind, randomized crossover study.Frontiers in sports and active living · 2025Article
- EEG β oscillations in aberrant data perception under cognitive load modulation.Scientific reports · 2024Article
- Brain Correlates of Eating Disorders in Response to Food Visual Stimuli: A Systematic Narrative Review of FMRI Studies.Brain sciences · 2023Review
- Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system.Current research in neurobiology · 2023Review
- Sensory representation of visual stimuli in the coupling of low-frequency phase to spike times.Brain structure & function · 2022Article
- Prefrontal Lesions Disrupt Posterior Alpha-Gamma Coordination of Visual Working Memory Representations.Journal of cognitive neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Storing information from incoming stimuli in working memory (WM) is essential for decision-making. The prefrontal cortex (PFC) plays a key role to support this process. Previous studies have characterized different neuronal populations in the PFC for working memory judgements based on whether an originally presented stimulus matches a subsequently presented one (matching-rule decision-making). However, much remains to be understood about this mechanism at the population level of PFC neurons. Here, we hypothesized differences in processing of feature vs. spatial WM within the PFC during a matching-rule decision-making task. To test this hypothesis, the modulation of neural activity within the PFC during two types of decision-making tasks (spatial WM and feature WM) in comparison to a passive fixation task was determined. We discovered that neural population-level activity within the PFC is different for the match vs. non-match condition exclusively in the case of the feature-specific decision-making task. For this task, the non-match condition exhibited a greater firing rate and lower trial-to-trial variability in spike count compared to the feature-match condition. Furthermore, the feature-match condition exhibited lower variability compared to the spatial-match condition. This was accompanied by a faster behavioral response time for the feature-match compared to the spatial-match WM task. We attribute this lower across-trial spiking variability and behavioral response time to a higher task-relevant attentional level in the feature WM compared to the spatial WM task. The findings support our hypothesis for task-specific differences in the processing of feature vs. spatial WM within the PFC. This also confirms the general conclusion that PFC neurons play an important role during the process of matching-rule governed decision-making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.