Evidence map›Paper›PMID 33398294›Full record

ArticlemedRxiv : the preprint server for health sciences2021

The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality from COVID-19.

Liam Rose, Laura Graham, Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Kenneth W Kinzler, Chetan Bettegowda, Bert Vogelstein, Susan Athey and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Liam RoseVA Health Economics Resource Center, Palo Alto VA, Menlo Park, CA, USA.
Laura GrahamVA Health Economics Resource Center, Palo Alto VA, Menlo Park, CA, USA.
Allison KoeneckeInstitute for Computational & Mathematical Engineering, Stanford University, Stanford, CA, USA.
Michael PowellDepartment of Biomedical Engineering, Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Ruoxuan XiongManagement Science & Engineering, Stanford University, Stanford, CA, USA.
Zhu ShenDepartment of Statistics, Stanford University, Stanford, CA, USA.
Kenneth W KinzlerLudwig Center, Lustgarten Laboratory, and the Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.
Chetan BettegowdaLudwig Center, Lustgarten Laboratory, and the Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.
Bert VogelsteinLudwig Center, Lustgarten Laboratory, and the Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.
Susan AtheyStanford Graduate School of Business, Stanford University, Stanford, CA, USA.
Joshua T VogelsteinDepartment of Biomedical Engineering, Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Maximilian F KonigLudwig Center, Lustgarten Laboratory, and the Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.
Todd H WagnerVA Health Economics Resource Center, Palo Alto VA, Menlo Park, CA, USA.
Howard Hughes Medical Institute · USStanford University · USVA Palo Alto Health Care System · USJohns Hopkins University · US

Funding

Multidisciplinary Rheumatology Training ProgramT32AR048522 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, LIVIA A CASCIOLA-ROSEN · 2003 to 2026
$6.4M
NIAMS NIH HHS T32 AR048522
6 · The paper itself

Abstract

Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and preclinical data suggest alpha-1 adrenergic receptor antagonists (α

Indexed as

alpha-1 adrenergic receptor antagonistcatecholamineCOVID-19doxazosinhyperinflammationin-hospital mortalityretrospective cohort studySARS-CoV-2

Identifiers

PMID33398294
PMCPMC7781337
OpenAlexW3116292603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.