Evidence map›Paper›PMID 33398198›Full record

SynthesisNature genetics2021

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

David V Conti, Burcu F Darst, Lilit C Moss, Edward J Saunders, Xin Sheng, Alisha Chou, Fredrick R Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev and 221 more

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 318 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
318citing papers in PubMed, 14 pooled it
71.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221168 recruitingnot on this map

ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

TypeobservationalSponsorCentre de Recherche sur les Pathologies ProstatiquesRan1996 to 2026Enrolled10,000ConditionsProstate Cancer
NCT05681416 nanot yet recruitingnot on this mapstarted 2023, after this paper: background citation

Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer

TypeinterventionalSponsorHeinrich-Heine University, DuesseldorfRan2023 to 2027Enrolled300ConditionsProstate Cancer, Familial Prostate CancerArmsPanel sequencing, whole exome sequencing, whole genome sequencing
3 · Its place in the literature

Who cites it

318 citing papers in PubMed, 14 syntheses or guidelines pooled it, 484 citations in OpenAlex.

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  10. Germline Genetic Variants Associated with Somatic TMPRSS2:ERG Fusion Status in Prostate Cancer: A Genome-Wide Association Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Pooled it
  11. Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
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258 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

231 authors at 20 institutions in 23 countries.

David V Conti *Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Burcu F Darst *Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6205-4632
Lilit C MossCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Edward J SaundersThe Institute of Cancer Research, London, UK.
Xin ShengCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Alisha ChouCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7521-6373
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3073-7463
Ali Amin Al OlamaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Sara BenllochCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Tokhir DadaevThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-8268-0438
Mark N BrookThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-8969-2378
Ali SahimiCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6893-4449
Atushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7099-8767
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.
Masashi FujitaLaboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-1457-6233
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-6429-988X
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Peggy WanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Victoria L StevensBehavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-0259-4407
Susan M GapsturBehavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA.
Brian D CarterBehavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA.
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-1863-0305
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Csilla SipekyInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-8853-4722
Anssi AuvinenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0003-1125-4818
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-4946-9099
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Robert J MacInnisCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Dominika WokołorczykInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan LubińskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
David E NealNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Jenny L DonovanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Richard M MartinPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7992-7719
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1954-7220
Sune F NielsenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Maren WeischerDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Stig E BojesenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4061-4133
Martin Andreas RøderCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0019-5333
Peter IversenCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4646-6247
Suzanne ChambersUniversity of Technology, Sydney, New South Wales, Australia.
Leire MoyaAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Lisa HorvathChris O'Brien Lifehouse (COBLH), Camperdown, Sydney, New South Wales, Australia.
Judith A ClementsAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Wayne TilleyDame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-1893-2626
Gail P RisbridgerDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-3089-4028
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1073-2753
Markus AlyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Robert SzulkinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Martin EklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5032-5266
Tobias NordströmDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4915-7546
Nora PashayanDepartment of Applied Health Research, University College London, London, UK.ORCID http://orcid.org/0000-0003-0843-2468
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Cambridge, UK.ORCID http://orcid.org/0000-0001-6651-7166
Maya GhoussainiOpen Targets, Wellcome Sanger Institute, Hinxton, UK.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9571-0763
Tim J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6795-6080
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6384-6447
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Hui-Yi LinSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3834-1535
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Edward GiovannucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Sara LindstromDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4472-8103
David J HunterNuffield Department of Population Health, University of Oxford, Oxford, UK.
Kathryn L PenneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, TX, USA.
Robert J HamiltonDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Neil E FleshnerDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Antonio FinelliDivision of Urology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Elaine A OstranderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6075-9738
Milan S GeybelsDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Meir StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Niclas HåkanssonDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7673-5554
Gerald L AndrioleWashington University School of Medicine, St Louis, MI, USA.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6538-9705
Karina Dalsgaard SørensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-4902-5490
Michael BorreDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Edward D YeboahUniversity of Ghana Medical School, Accra, Ghana.
James E MensahUniversity of Ghana Medical School, Accra, Ghana.ORCID http://orcid.org/0000-0003-4133-1722
Yong-Jie LuCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.ORCID http://orcid.org/0000-0001-6174-6621
Hong-Wei ZhangSecond Military Medical University, Shanghai, China.
Ninghan FengWuxi Second Hospital, Nanjing Medical University, Wuxi, China.
Xueying MaoCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.
Yudong WuDepartment of Urology, First Affiliated Hospital, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Shan-Chao ZhaoDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zan SunThe People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, China.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Shannon K McDonnellDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Daniel J SchaidDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Catharine M L WestDivision of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0002-0839-3449
Neil BurnetDivision of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, and The Christie NHS Foundation Trust, Manchester, UK.
Gill BarnettUniversity of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Christiane MaierHumangenetik Tuebingen, Tuebingen, Germany.
Thomas SchnoellerDepartment of Urology, University Hospital, Ulm, Germany.
Manuel Luedekegenetikum, Neu-Ulm, Germany.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.
Bettina F DrakeWashington University School of Medicine, St Louis, MI, USA.
Olivier CussenotSorbonne Universite, Tenon Hospital, Paris, France.
Géraldine Cancel-TassinSorbonne Universite, Tenon Hospital, Paris, France.ORCID http://orcid.org/0000-0002-9583-6382
Florence MenegauxExposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France.
Thérèse TruongExposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France.ORCID http://orcid.org/0000-0002-2943-6786
Yves Akoli KoudouCESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Villejuif, France.
Esther M JohnDepartment of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Lovise MaehleDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, UK.
Sue A InglesDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Mariana C SternDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Ana VegaFundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.ORCID http://orcid.org/0000-0002-7416-5137
Antonio Gómez-CaamañoDepartment of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-9773-4590
Laura FachalCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.ORCID http://orcid.org/0000-0002-7256-9752
Barry S RosensteinDepartment of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sarah L KernsDepartment of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-6503-0011
Harry OstrerDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-2209-5376
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.ORCID http://orcid.org/0000-0002-4896-5982
Paula PauloDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Andreia BrandãoDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.ORCID http://orcid.org/0000-0003-0938-1543
Stephen WatyaUro Care, Kampala, Uganda.
Alexander LubwamaUro Care, Kampala, Uganda.
Jeannette T BensenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Elizabeth T H FonthamDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
James MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Manolis KogevinasISGlobal, Barcelona, Spain.
Javier LlorcaCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Gemma Castaño-VinyalsISGlobal, Barcelona, Spain.
Lisa Cannon-AlbrightDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-2602-3668
Craig C TeerlinkDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Chad D HuffDepartment of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Sara S StromDepartment of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Luc MultignerUniversity of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Rennes, France.ORCID http://orcid.org/0000-0003-3205-8568
Pascal BlanchetCHU de Pointe-à-Pitre, University of the French Antilles, University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, France.
Laurent BrureauCHU de Pointe-à-Pitre, University of the French Antilles, University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, France.
Radka KanevaMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Chavdar SlavovDepartment of Urology and Alexandrovska University Hospital, Medical University of Sofia, Sofia, Bulgaria.
Vanio MitevMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Robin J LeachDepartment of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Brandi WeaverDepartment of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Katarina CukDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.
Kai-Uwe SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eric A KleinCleveland Clinic Lerner Research Institute, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1783-0698
Ann W HsingDepartment of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Rick A KittlesDivision of Health Equities, Department of Population Sciences, City of Hope, Duarte, CA, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9977-3473
Christopher J LogothetisDepartment of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Jeri KimDepartment of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Linda SteeleDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Anselm J M HennisDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
John CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hardev PandhaFaculty of Health and Medical Sciences, The University of Surrey, Guildford, UK.
Agnieszka MichaelFaculty of Health and Medical Sciences, The University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-7262-6227
Kim De RuyckDepartment of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium.
Gert De MeerleerDepartment of Radiotherapy, Ghent University Hospital, Gent, Belgium.
Piet OstDepartment of Radiotherapy, Ghent University Hospital, Gent, Belgium.ORCID http://orcid.org/0000-0002-2203-4848
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-1343-8752
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jasmine LimDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Soo-Hwang TeoCancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Malaysia.ORCID http://orcid.org/0000-0002-0444-590X
Lisa F NewcombDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Daniel W LinDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Jay H FowkeDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Marija GamulinDepartment of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
Davor LesselInstitute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4496-244X
Tomislav KulisDepartment of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.ORCID http://orcid.org/0000-0002-0895-5691
Nawaid UsmaniDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Sandeep SinghalDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Matthew ParliamentDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Frank ClaessensMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium.
Steven JoniauDepartment of Urology, University Hospitals Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3195-9890
Thomas Van den BroeckMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
Jose Esteban CastelaoGenetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo, Spain.
Maria Elena MartinezMoores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Samantha LarkinThe University of Southampton, Southampton General Hospital, Southampton, UK.
Paul A TownsendFaculty of Health and Medical Sciences, The University of Surrey, Guildford, UK.
Claire Aukim-HastieFaculty of Health and Medical Sciences, The University of Surrey, Guildford, UK.
William S BushCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-9729-6519
Melinda C AldrichDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Dana C CrawfordCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-6437-6248
Shiv SrivastavaCenter for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA.
Jennifer C CullenCenter for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA.
Gyorgy PetrovicsCenter for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA.
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Monique J RoobolDepartment of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6967-1708
Guido JensterDepartment of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-8658-2552
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jennifer J HuThe University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.
Rohit VarmaSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Roberta McKean-CowdinCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Mina TorresSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Nicholas MancusoCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente, Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-5599-8387
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4623-0544
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Rosalind A EelesThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3698-6241
Zsofia Kote-JaraiThe Institute of Cancer Research, London, UK.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA. haiman@usc.edu.ORCID http://orcid.org/0000-0002-0097-9971
University of Southern California · USNational Cancer Institute · USUniversity of Cambridge · GBInserm · FRKarolinska Institutet · SEManchester Academic Health Science Centre · GBCity of Hope · USHarvard University · USInstitute of Cancer Research · GBThe University of Texas MD Anderson Cancer Center · USUniversity of Washington · USAmerican Cancer Society · USBrigham and Women's Hospital · USErasmus MC · NLFred Hutch Cancer Center · USGerman Cancer Research Center · DEInternational Hereditary Cancer Center · PLMedical University of Sofia · BGRIKEN Center for Integrative Medical Sciences · JPTranslational Research Institute · AU

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI William JAMES GAUDERMAN · 2016 to 2026
$25.5M
Genetic EpidemiologyZIACP005803 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GOLDSTEIN, ALISA · 2009 to 2025
$24.8M
Finding Genes for Human Prostate CancerZIAHG200325 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2009 to 2021
$17.7M
Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas SouthwesternU01CA113913 · NCI · EMORY UNIVERSITY · PI Martin G. Sanda · 2005 to 2026
$16.4M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
Quantifying and Characterizing the shared genetic contribution to common cancersU01CA194393 · NCI · UNIVERSITY OF WASHINGTON · PI KRAFT, PETER, LINDSTROEM, SARA · 2015 to 2023
$3.0M
Cancer Research UK 17528Cancer Research UK 29017Cancer Research UK 29019Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS K99 CA246063NCI NIH HHS P01 CA196569NCI NIH HHS R00 CA246063NCI NIH HHS R01 CA194393NCI NIH HHS U01 CA113913NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA194393NCI NIH HHS U01 CA261339NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148537NCI NIH HHS UG1 CA189974NIEHS NIH HHS P30 ES010126Wellcome Trust 203477/Z/16/Z
6 · The paper itself

Abstract

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

Indexed as

Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedMolecular Sequence AnnotationNeoplasm InvasivenessOdds RatioProstatic NeoplasmsRacial GroupsRisk Factors

Identifiers

PMID33398198
PMCPMC8148035
OpenAlexW3115151307

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.