ArticleNature cell biology2021
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 78 citations in OpenAlex.
- Intestinal Stem Cells: Regulation, Plasticity, and Therapeutic Potential.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Charting Endocrine Progenitors Across Species and Organs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic cell fate transitions during morphallactic regeneration.Nature communications · 2026Article
- Hyperoxia-induced lung microvascular injury is mediated by endothelial cell-derived WNT5A.Journal of thoracic disease · 2026Article
- Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation.Communications biology · 2026Article
- Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis.NPJ biofilms and microbiomes · 2026Article
- Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake.International journal of biological sciences · 2026Article
- Nicheformer: a foundation model for single-cell and spatial omics.Nature methods · 2025Article
- Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polarity.bioRxiv : the preprint server for biology · 2025Article
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
- High-dose tamoxifen impairs the homeostasis of the intestinal stem cell niche by enhancing fatty acid degradation and damaging mitochondria.Apoptosis : an international journal on programmed cell death · 2025Article
- Enteroendocrine cell differentiation: Implications for human disease.Molecular and cellular endocrinology · 2025Review
- Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients.Nature communications · 2025Article
- Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data.Nature communications · 2025Article
- The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses.Stem cell research & therapy · 2025Article
- Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation.Inflammation · 2025Article
- Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility.Developmental cell · 2025Article
- NiCo identifies extrinsic drivers of cell state modulation by niche covariation analysis.Nature communications · 2024Article
- Cell competition in primary and metastatic colorectal cancer.Oncogenesis · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 2 institutions in 1 country.
Anika BöttcherInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-5473-3136
Maren BüttnerInstitute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6189-3792
Sophie TritschlerInstitute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-0977-9957
Michael SterrInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.
Alexandra AliluevInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.
Lena OppenländerInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.
Ingo BurtscherInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.
Steffen SassInstitute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.
Martin IrmlerGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3169-479X
Johannes BeckersGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Christoph ZiegenhainDepartment Biology II, Anthropology and Human Genomics, Ludwig-Maximilians-University of Munich, Martinsried, Germany.ORCID http://orcid.org/0000-0003-2208-4877
Wolfgang EnardDepartment Biology II, Anthropology and Human Genomics, Ludwig-Maximilians-University of Munich, Martinsried, Germany.
Andrea C SchambergerComprehensive Pneumology Center, Helmholtz Center Munich, Munich, Germany.
Fien M VerhammeComprehensive Pneumology Center, Helmholtz Center Munich, Munich, Germany.
Oliver EickelbergComprehensive Pneumology Center, Helmholtz Center Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7170-0360
Fabian J TheisInstitute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany. fabian.theis@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-2419-1943
Heiko LickertInstitute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany. heiko.lickert@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-4597-8825
Helmholtz Zentrum München · DELudwig-Maximilians-Universität München · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
A detailed understanding of intestinal stem cell (ISC) self-renewal and differentiation is required to treat chronic intestinal diseases. However, the different models of ISC lineage hierarchy
Indexed as
Cell LineageCell PolarityAnimalsbeta CateninCell Self RenewalEnteroendocrine CellsFemaleGene Expression ProfilingIntestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutPaneth CellsReceptors, G-Protein-CoupledSingle-Cell Analysisbeta CateninCTNNB1 protein, mouseLgr5 protein, mouseReceptors, G-Protein-CoupledWnt Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.