Evidence map›Paper›PMID 33398087›Full record

ArticleMolecular psychiatry2021

Bioenergetics and abnormal functional connectivity in psychotic disorders.

Xiaopeng Song, Xi Chen, Cagri Yuksel, Junliang Yuan, Diego A Pizzagalli, Brent Forester, Dost Öngür, Fei Du

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
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  4. Review
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  8. Article
  9. Neural Patterns of Social Pain in the Brain-Wide Representations Across Social Contexts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. mPFC DCC coupling with CaMKIITranslational psychiatry · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. An NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond: Research Agenda on Phenomenology, Clinical Trajectories, Underlying Mechanisms, and Intervention Targets.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Review
  16. Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaopeng Song *Psychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA.ORCID http://orcid.org/0000-0003-0074-6489
Xi Chen *Psychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA.
Cagri YukselPsychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA.
Junliang YuanMcLean Imaging Center, McLean Hospital, Belmont, MA, 02478, USA.
Diego A PizzagalliMcLean Imaging Center, McLean Hospital, Belmont, MA, 02478, USA.ORCID http://orcid.org/0000-0002-7772-1143
Brent ForesterHarvard Medical School, Boston, MA, 02115, USA.
Dost ÖngürPsychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA.
Fei DuPsychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA. fdu@mclean.harvard.edu.ORCID http://orcid.org/0000-0002-9549-4255
Harvard University · USPeking University · CN

Funding

Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)P50MH115846 · NIMH · MCLEAN HOSPITAL · PI MIGUEL HERNAN · 2019 to 2026
$16.9M
Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's DementiaR01AG066670 · NIA · MCLEAN HOSPITAL · PI DU, FEI, FORESTER, BRENT PETER · 2020 to 2024
$4.0M
Molecular Mechanisms and Biomarkers for Disease Progression from Prodrome to Early PsychosisR01MH114982 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, ONGUR, DOST · 2019 to 2023
$2.4M
Brain bioenergetics and slow wave activity in first episode psychosisK23MH119322 · NIMH · MCLEAN HOSPITAL · PI YUKSEL, ABDULLAH CAGRI · 2020 to 2024
$852k
Research and Mentoring on Brain and Peripheral Bioenergetics in SchizophreniaK24MH104449 · NIMH · MCLEAN HOSPITAL · PI ONGUR, DOST · 2015 to 2019
$749k
Oxidative Stress in First Episode Schizophrenia Assessed in vivo Using NAD+ and NADH MeasurementR21MH114020 · NIMH · MCLEAN HOSPITAL · PI DU, FEI · 2017 to 2018
$451k
NIA NIH HHS R01 AG066670NIMH NIH HHS K24 MH104449NIMH NIH HHS P50 MH115846NIMH NIH HHS R01 MH114982NIMH NIH HHS R21 MH114020U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH119322
6 · The paper itself

Abstract

Psychotic Disorders such as schizophrenia (SZ) and bipolar disorder (BD) are characterized by abnormal functional connectivity (FC) within neural networks such as the default mode network (DMN), as well as attenuated anticorrelation between DMN and task-positive networks (TPN). Bioenergetic processes are critical for synaptic connectivity and are also abnormal in psychotic disorders. We therefore examined the association between brain energy metabolism and FC in psychotic disorders.

Indexed as

Bipolar DisorderPsychotic DisordersBrainBrain MappingEnergy MetabolismHumansMagnetic Resonance Imaging

Identifiers

PMID33398087
PMCPMC8254819
OpenAlexW3118751097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.