ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Salivary beta-endorphin in nonsuicidal self-injury: an ambulatory assessment study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A Systematic Review of Ecological Momentary Assessment Procedures of Self-Harm (With and Without Suicidal Intent) Studies in Adolescents and Young Adults.International journal of environmental research and public health · 2026Pooled it
- A bibliometric analysis and visualization of non-suicidal self-injury in adolescents.Frontiers in psychiatry · 2024Pooled it
- A meta-analysis on the affect regulation function of real-time self-injurious thoughts and behaviours.Nature human behaviour · 2022Pooled it
- The effect of mindfulness-based cognitive therapy on non-suicidal self-injury in hospitalized adolescents with depressive disorders: a randomized controlled trial.Psychological medicine · 2026Trial
- Major Depressive Disorder With Non-Suicidal Self-Injury in Adolescents: Altered Morphological Inverse Divergence Gradient in Brain Structure and Gene Expression Patterns.Human brain mapping · 2026Article
- Non-Suicidal Self-Injury in Adolescents With Major Depressive Disorder: The Role of Beta-Endorphin, Psychological Pain, and Anhedonia.Alpha psychiatry · 2026Article
- [Research progress on influencing factors and biological mechanisms of non-suicidal self-injury in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Capturing affective states in everyday life - Comparing psychometric properties of two affect measures.Neuroscience applied · 2026Article
- Case Report: When pain is shown and silenced. adolescents looking for a voice.Frontiers in child and adolescent psychiatry · 2026Article
- Association Between Opioid Analgesics and Suicide Attempts: A Nationwide French Case-Crossover Study.CNS drugs · 2025Observational
- Nonrestorative sleep is associated with self-injury behavior and suicidal ideation in Chinese adolescents: a longitudinal study.BMC public health · 2025Article
- Borderline Personality Symptoms, Body Modification, and Emotional Regulation.International journal of environmental research and public health · 2025Article
- Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury.Frontiers in psychiatry · 2025Article
- Give me five! A modern perspective on addiction from the up-dated Freudian drive theory.Frontiers in psychiatry · 2025Article
- Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma.Molecular psychiatry · 2024Article
- Specific Salivary Neuropeptides Shift Synchronously during Acute Stress in Fire Recruits.Brain sciences · 2024Article
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder.Current psychiatry reports · 2024Review
- TheFrontiers in psychology · 2024Article
- Pain before, during, and after nonsuicidal self-injury: Findings from a large web study.Journal of psychopathology and clinical science · 2023Article
- Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review.General psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonsuicidal self-injury (NSSI) is a prevalent and impairing behavior, affecting individuals with and without additional psychopathology. To shed further light on biological processes that precede and result from NSSI acts, we built on previous cross-sectional evidence suggesting that the endogenous opioid system, and especially β-endorphin, is involved in the psychopathology of NSSI. This is the first study assessing salivary β-endorphin in daily life in the context of NSSI acts. Fifty-one female adults with repetitive NSSI participated over a period of 15 days in an ambulatory assessment study. Salivary β-endorphin was assessed before and after engagement in NSSI, during high urge for NSSI, and on a non-NSSI day. Furthermore, NSSI specific variables such as pain ratings, as well as method, severity, and function of NSSI were assessed. We found that β-endorphin levels immediately before an NSSI act were significantly lower than directly after NSSI. However, there was no difference between β-endorphin during high urge for NSSI and post NSSI measures. We found a positive association between severity of the self-inflicted injury and β-endorphin levels, but no significant association between β-endorphin levels and subjectively experienced pain. The results of the present study indicate that it is possible to assess salivary β-endorphin in daily life in the context of NSSI. Furthermore, our results provide a first indication that NSSI acts could be associated with a momentary increase of β-endorphin, and this might reinforce NSSI engagement. More research is needed to replicate and extend our findings on peripheral β-endorphin in daily life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.