Evidence map›Paper›PMID 33398066›Full record

ArticleBritish journal of cancer2021

Dairy intake during adolescence and risk of colorectal adenoma later in life.

Katharina Nimptsch, Dong Hoon Lee, Xuehong Zhang, Mingyang Song, Maryam S Farvid, Leandro F M Rezende, Yin Cao, Andrew T Chan, Charles Fuchs, Jeffrey Meyerhardt and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Postbiotics, Metabolic Signaling, and Cancer.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Katharina NimptschMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. katharina.nimptsch@mdc-berlin.de.ORCID http://orcid.org/0000-0001-7877-205X
Dong Hoon LeeDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xuehong ZhangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mingyang SongDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1324-0316
Maryam S FarvidDepartment of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, USA.
Leandro F M RezendeUniversidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Preventiva, Sao Paulo, SP, Brazil.
Yin CaoDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
Andrew T ChanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Charles FuchsYale Cancer Center, New Haven, CT, USA.
Jeffrey MeyerhardtDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jonathan A NowakProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Shuji OginoDepartment of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3909-2323
Edward GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tobias PischonMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0003-1568-767X
Kana WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Accelerating Transdisciplinary Epidemiology of Colorectal CancerR35CA197735 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2015 to 2021
$6.0M
Calcium and Colorectal Cancer: Gene-Environment Interactions and Molecular PathwaysK07CA188126 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, XUEHONG · 2015 to 2018
$576k
Optimizing the Impact of Aspirin for ChemopreventionK07CA218377 · NCI · WASHINGTON UNIVERSITY · PI CAO, YIN · 2018 to 2021
$504k
Integrating diet, lifestyle and tumor tissue molecular subtyping to study the role of adolescent calcium intake on the risk of early onset colorectal neoplasiaR21CA230873 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI OGINO, SHUJI, WU, KANA · 2018 to 2019
$427k
Integrating diet and tissue whole exome sequencing data to study processed meat and colorectal cancerR21CA222940 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GIANNAKIS, MARIOS, WU, KANA · 2018 to 2019
$421k
Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer PreventionK99CA215314 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SONG, MINGYANG · 2018 to 2018
$179k
Early life risk factors and risk of colorectal neoplasiaR03CA197879 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WU, KANA · 2015 to 2016
$162k
NCI NIH HHS K07 CA188126NCI NIH HHS K07 CA218377NCI NIH HHS K99 CA215314NCI NIH HHS R03 CA197879NCI NIH HHS R21 CA222940NCI NIH HHS R21 CA230873NCI NIH HHS R35 CA197735
6 · The paper itself

Abstract

backgroundHigher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is associated with lower risk of colorectal adenoma, a colorectal cancer precursor.

methodsIn 27,196 females from the Nurses' Health Study 2, aged 25-42 years at recruitment (1989), who had completed a validated high school diet questionnaire in 1998 and undergone at least one lower bowel endoscopy between 1998 and 2011, logistic regression for clustered data was used to calculate odds ratios (ORs) and 95% confidence intervals (CI).

resultsColorectal adenomas were diagnosed in 2239 women. Dairy consumption during adolescence was not associated with colorectal adenoma risk (OR highest vs. lowest [≥4 vs. ≤1.42 servings/day] quintile [95% CI] 0.94 [0.80, 1.11]). By anatomical site, higher adolescent dairy intake was associated with lower rectal (0.63 [0.42, 0.95]), but not proximal (1.01 [0.80, 1.28]) or distal (0.97 [0.76, 1.24]) colon adenoma risk. An inverse association was observed with histologically advanced (0.72 [0.51, 1.00]) but not non-advanced (1.07 [0.86, 1.33]) adenoma.

conclusionsIn this large cohort of younger women, higher adolescent dairy intake was associated with lower rectal and advanced adenoma risk later in life.

Indexed as

DietFeeding BehaviorAdenomaAdolescentAdultColorectal NeoplasmsDairy ProductsFemaleFollow-Up StudiesHumansPrognosisProspective StudiesRisk FactorsSurveys and QuestionnairesUnited States

Identifiers

PMID33398066
PMCPMC7960961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.