ArticleNature communications2021
Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed.
- Article
- In utero exposure to anti-Caspr2 antibody disrupts parvalbumin interneuron function in the hippocampus.Brain, behavior, and immunity · 2026Article
- Rethinking parvalbumin: From passive marker to active modulator of hippocampal circuits.IBRO neuroscience reports · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.Neuron · 2025Article
- Fast-spiking parvalbumin-positive interneurons: new perspectives of treatment and future challenges in dementia.Molecular psychiatry · 2025Review
- Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.bioRxiv : the preprint server for biology · 2025Article
- Navigating Cardiovascular Challenges of Obesity: Exploring Preventive Approaches.Endocrine, metabolic & immune disorders drug targets · 2025Review
- HCN1 hyperpolarization-activated cyclic nucleotide-gated channels enhance evoked GABA release from parvalbumin-positive interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus.Molecular psychiatry · 2024Article
- High-throughput analysis of dendrite and axonal arbors reveals transcriptomic correlates of neuroanatomy.Nature communications · 2024Article
- Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gamma oscillation plasticity is mediated via parvalbumin interneurons.Science advances · 2024Article
- Integrating single-cell transcriptomics with cellular phenotypes: cell morphology, CaBiophysical reviews · 2024Review
- Hippocampal GABAergic interneurons and memory.Neuron · 2023Review
- Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.Communications biology · 2023Article
- Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons.bioRxiv : the preprint server for biology · 2023Article
- Microisolation of Spatially Characterized Single Populations of Neurons for RNA Sequencing from Mouse and Postmortem Human Brain Tissues.Journal of clinical medicine · 2023Article
- Commissural dentate granule cell projections and their rapid formation in the adult brain.PNAS nexus · 2023Article
- N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited the identification of several known cell types. In this study, we used single-cell RNA-seq in morphologically identified parvalbumin interneurons (PV-INs), and studied their transcriptomic states in the morphological, physiological, and developmental domains. Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types. Furthermore, PV-INs show a uniform synaptic cell adhesion molecule (CAM) profile, suggesting that CAM expression in mature PV cells does not reflect wiring specificity after development. Together, our results suggest that while PV-INs differ in anatomy and in vivo activity, their continuous transcriptomic and homogenous biophysical landscapes are not predictive of these distinct identities.
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