ArticleNature communications2021
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
Abstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
132 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Meta-Analysis of Rhesus Macaques (Comparative medicine · 2021Pooled it
- Pooled it
- Intranasal infection of Rift Valley fever virus in the ferret model suggests multiple routes of neuroinvasion with consequential encephalitis and ophthalmitis.Scientific reports · 2026Article
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- Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.Nature biotechnology · 2025Article
- Development of ferret immune repertoire reference resources and single-cell-based high-throughput profiling assays.Journal of virology · 2025Article
- Reverse transcription-quantitative PCR assays for detecting SARS-CoV-2 using subgenomic RNA load.Heliyon · 2025Article
- Article
- Comparative temporal transcriptome analyses of SARS-CoV-2 delta and omicron variants ex-vivo infection in cat lung explant culture.Frontiers in cellular and infection microbiology · 2025Article
- Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.Virulence · 2024Review
- Animal models of Long Covid: A hit-and-run disease.Science translational medicine · 2024Review
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.Genome medicine · 2024Article
- Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection.PLoS pathogens · 2024Article
- Article
- Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice.Immune network · 2024Article
- Care, management, and use of ferrets in biomedical research.Laboratory animal research · 2024Review
- SARS-CoV-2 infection in animals: Patterns, transmission routes, and drivers.Eco-Environment & Health · 2024Review
- An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission.Nature communications · 2024Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors.
Kathryn A RyanNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0001-8608-1144
Kevin R BewleyNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-9078-6734
Susan A FotheringhamNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Gillian S SlackNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Phillip BrownNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0001-6367-6495
Yper HallNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Nadina I WandNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-5518-4367
Anthony C MarriottNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-8862-9852
Breeze E CavellNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0001-9897-1590
Julia A TreeNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Lauren AllenNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Marilyn J AramNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Thomas J BeanNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Emily BruntNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Karen R ButtigiegNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Daniel P CarterNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-8021-9277
Rebecca CobbNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Naomi S CoombesNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Steve J Findlay-WilsonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Kerry J GodwinNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Karen E GoochNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Jade GourietNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Rachel HalkerstonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Debbie J HarrisNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Thomas H HenderNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Holly E HumphriesNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0003-2576-8502
Laura HunterNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Catherine M K HoNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Chelsea L KennardNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Stephanie LeungNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Stephanie LongetNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0001-5026-431X
Didier NgaboNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0003-1818-1439
Karen L OsmanNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-8095-3850
Jemma PatersonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Elizabeth J PennNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Steven T PullanNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Emma RaynerNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Oliver SkinnerNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Kimberley SteedsNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Irene TaylorNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Tom TiptonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-0573-528X
Stephen ThomasNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Carrie TurnerNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Robert J WatsonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Nathan R WiblinNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Sue CharltonNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Bassam HallisNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Julian A HiscoxInstitute of Infection and Global Health, University of Liverpool, Liverpool, L69 2BE, UK.
Simon FunnellNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.ORCID 0000-0002-4254-2751
Mike J DennisNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Catherine J WhittakerNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Michael G CattonVictorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Julian DruceVictorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Francisco J SalgueroNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Miles W CarrollNational Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP4 0JG, UK. miles.carroll@phe.gov.uk.
Funding
Understanding Obesity In Relation to the Built EnvironmentP20MD006899 · NIMHD · JACKSON STATE UNIVERSITY · PI ANTOINE-LAVIGNE, DONNA A · 2012 to 2016
$5.3MNIMHD NIH HHS P20 MD006899
Abstract
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model. After a high (5 × 10
Indexed as
Disease Models, AnimalAnimalsAntibodies, ViralCOVID-19COVID-19 VaccinesDose-Response Relationship, DrugFemaleFerretsLungRNA, ViralSARS-CoV-2Virus ReplicationVirus SheddingAntibodies, ViralCOVID-19 VaccinesRNA, Viral
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.