ArticleNPJ breast cancer2021
Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients.
Article in NPJ breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Photon-counting detector CT in oncology: a new era of cancer imaging.Insights into imaging · 2026Review
- Feasibility of opportunistic dental diagnostics in routine photon-counting CT examinations of the cervical spine.BMC oral health · 2026Article
- The speed of sound in skull-mimicking digital phantoms depends on the microstructure.Physics in medicine and biology · 2025Article
- Influence of bone microstructure on ultrasound loss through skull-mimicking digital phantoms.Medical physics · 2025Article
- Applications of photon-counting CT in oncologic imaging: A systematic review.World journal of radiology · 2025Article
- Review
- Effect of trabecular architectures on the mechanical response in osteoporotic and healthy human bone.Medical & biological engineering & computing · 2024Article
- Chances and challenges of photon-counting CT in musculoskeletal imaging.Skeletal radiology · 2024Review
- Introduction to Special Issue Imaging in Cancer Diagnosis.Tomography (Ann Arbor, Mich.) · 2024Article
- Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.Radiology · 2023Review
- Clinical applications of photon counting detector CT.European radiology · 2023Review
- Photon-counting CT allows better visualization of temporal bone structures in comparison with current generation multi-detector CT.Insights into imaging · 2023Article
- Photon-counting detector CT: early clinical experience review.The British journal of radiology · 2023Review
- Ultrahigh resolution whole body photon counting computed tomography as a novel versatile tool for translational research from mouse to man.Zeitschrift fur medizinische Physik · 2023Article
- Effects of non-stationary blur on texture biomarkers of bone using Ultra-High Resolution CT.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Imaging in translational cancer research.Cancer biology & medicine · 2022Review
- Spectral Photon-Counting Computed Tomography: A Review on Technical Principles and Clinical Applications.Journal of imaging · 2022Review
- Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients.NPJ breast cancer · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional CT scanners use energy-integrating detectors (EIDs). Photon-counting detector (PCD) computed tomography (CT) utilizes a CT detector technology based on smaller detector pixels capable of counting single photons and in addition discriminating their energy. Goal of this study was to explore the potential of higher spatial resolution for imaging of bone metastases. Four female patients with histologically confirmed breast cancer and bone metastases were included between July and October 2019. All patients underwent conventional EID CT scans followed by a high resolution non-contrast experimental PCD CT scan. Ultra-high resolution (UHR) reconstruction kernels were used to reconstruct axial slices with voxel sizes of 0.3 mm × 0.3 mm (inplane) × 1 mm (z-direction). Four radiologists blinded for patient identity assessed the images and compared the quality to conventional CT using a qualitative Likert scale. In this case series, we present images of bone metastases in breast cancer patients using an experimental PCD CT scanner and ultra-high-resolution kernels. A tendency to both a smaller inter-reader variability in the structural assessment of lesion sizes and in the readers' opinion to an improved visualization of lesion margins and content was observed. In conclusion, while further studies are warranted, PCD CT has a high potential for therapy monitoring in breast cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.