Evidence map›Paper›PMID 33397999›Full record

ReviewNPJ Regenerative medicine2021

Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin.

Janak Gaire, Justin A Varholick, Sabhya Rana, Michael D Sunshine, Sylvain Doré, W Brad Barbazuk, David D Fuller, Malcolm Maden, Chelsey S Simmons

Open access · goldAbstract readReview
In one paragraph

Review in NPJ Regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Behavioral and Functional Profiling ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Efficacy and Pharmacokinetics of 3 Sustained-Release Buprenorphine Formulations in Cairo Spiny Mice (Acomys cahirinus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  9. Review
  10. Article
  11. Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius).Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Osteogenic shift in the adipose-derived stem cells ofFrontiers in cell and developmental biology · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Janak GaireDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0002-1862-8360
Justin A VarholickDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0003-2822-9045
Sabhya RanaDepartment of Physical Therapy, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0002-1303-6614
Michael D SunshineDepartment of Physical Therapy, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0002-7133-4185
Sylvain DoréDepartment of Anesthesiology, University of Florida, Gainesville, 32611, USA.
W Brad BarbazukDepartment of Biology and UF Genetics Institute, University of Florida, Gainesville, 32611, USA.
David D FullerDepartment of Physical Therapy, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0001-5013-5972
Malcolm MadenDepartment of Biology and UF Genetics Institute, University of Florida, Gainesville, 32611, USA.ORCID http://orcid.org/0000-0001-7178-5309
Chelsey S SimmonsDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, 32611, USA. css@ufl.edu.ORCID http://orcid.org/0000-0001-6973-9813
University of Florida · USAllen Institute for Brain Science · US

Funding

Training Program in Regenerative MedicineT32DK074367 · NIDDK · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2007 to 2022
$2.9M
Model Systems of Mammalian RegenerationR35GM128831 · NIGMS · UNIVERSITY OF FLORIDA · PI SIMMONS, CHELSEY SAVANNAH · 2018 to 2022
$1.8M
Genetic Modification to Harness the Regenerative Power of the African Spiny MouseR21OD028211 · OD · UNIVERSITY OF FLORIDA · PI MADEN, MALCOLM · 2019 to 2020
$419k
A Single cell expression atlas of muscle and dermis during regeneration after wounding in Acomys cahirinus - an adult mammal model for de novo muscle regenerationR21OD028209 · OD · UNIVERSITY OF FLORIDA · PI BARBAZUK, WILLIAM B · 2019 to 2020
$415k
National Science Foundation (NSF) 1636007NIDDK NIH HHS T32 DK074367NIGMS NIH HHS R35 GM128831NIH HHS R21 OD028209NIH HHS R21 OD028211U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21OD028209U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21OD028211U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM128831
6 · The paper itself

Abstract

The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.

Identifiers

PMID33397999
PMCPMC7782534
OpenAlexW3119565214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.