ArticleNature communications2021
Bis-silylation of internal alkynes enabled by Ni(0) catalysis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cobalt-catalyzed alkyne silylamidation unlocksNational science review · 2026Article
- A DMAP-enabled strategy for C(spNature communications · 2025Article
- Modular Synthesis of New Metalloid-Substituted Olefins from Diboryl(Silyl)Ethenes via Suzuki-Miyaura Reactions.International journal of molecular sciences · 2024Article
- Disilane-bridged architectures: an emerging class of molecular materials.Chemical science · 2023Review
- Rhodium-CatalyzedMolecules (Basel, Switzerland) · 2023Article
- Synthesis of Pyridine-Fused Siloles by Palladium-Catalyzed Intramolecular Bis-Silylation.ACS omega · 2022Article
- Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids.Nature communications · 2022Article
- Theoretical investigation on the effect of the ligand on bis-silylation of C(sp)-C(sp) by Ni complexes.RSC advances · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
1,2-Bis-silyl alkenes have exciting synthetic potential for programmable sequential synthesis via manipulation of the two vicinal silyl groups. Transition metal-catalyzed bis-silylation of alkynes with disilanes is the most straightforward strategy to access such useful building blocks. However, this process has some limitations: (1) symmetric disilanes are frequently employed in most of the reactions to assemble two identical silyl groups, which makes chemoselective differentiation for stepwise downstream transformations difficult; (2) the main catalysts are low-valent platinum group transition metal complexes, which are expensive; and (3) internal alkynes remain challenging substrates with low inherent reactivity. Thus, the development of abundant metal-catalyzed bis-silylation of internal alkynes with unsymmetrical disilanes is of significance. Herein, we solve most of the aforementioned limitations in bis-silylation of unsaturated bonds by developing a strongly coordinating disilane reagent and a Ni(0) catalytic system. Importantly, we sufficiently realize the stepwise recognition of the two silyl groups, making this synthetic protocol of wide potential utility.
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Registered trials
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