Evidence map›Paper›PMID 33397917›Full record

ArticleNature communications2021

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.

Daohua Jiang, Lige Tonggu, Tamer M Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A Catterall

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Structural basis of inhibition of human NaNature communications · 2025
    Article
  9. Voltage sensors.Molecular pharmacology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. A structural atlas of druggable sites on NaChannels (Austin, Tex.) · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Structural basis of inhibition of human NabioRxiv : the preprint server for biology · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Daohua JiangDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA.
Lige TongguDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-0033-556X
Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA.
Richard BanhMolecular Medicine, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Régis PomèsMolecular Medicine, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.ORCID http://orcid.org/0000-0003-3068-9833
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA. nzheng@uw.edu.ORCID http://orcid.org/0000-0002-1039-1581
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA. wcatt@uw.edu.ORCID http://orcid.org/0000-0001-5509-3580
University of Washington · USUniversity of Toronto · CAHoward Hughes Medical Institute · US

Funding

Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
Sodium and Calcium Channels: Structure, Function, Neuroplasticity, and DiseaseR35NS111573 · NINDS · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2019 to 2024
$6.1M
Acquisition of a high resolution, high throughput cryo-electron microscopeS10OD023476 · OD · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M · 2017 to 2017
$2.0M
CIHR MOP130461Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL112808NIH HHS S10 OD023476NINDS NIH HHS R35 NS111573
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

AnimalsBinding SitesCryoelectron MicroscopyHEK293 CellsHumansIon Channel GatingMolecular Dynamics SimulationMyocardiumNAV1.5 Voltage-Gated Sodium ChannelProtein ConformationRatsScorpion VenomsSodiumNAV1.5 Voltage-Gated Sodium ChannelScorpion VenomsSodium

Identifiers

PMID33397917
PMCPMC7782738
OpenAlexW3119630433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.