ReviewJournal of immunology (Baltimore, Md. : 1950)2021
Afferent Lymphatic Transport and Peripheral Tissue Immunity.
Review in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Phenotypic alterations in the immune system and tolerance induction in tumor-draining lymph nodes.Iranian journal of basic medical sciences · 2026Review
- Beyond Drainage: How Lymphatic Vessels Instruct Immune Cell Fate.Journal of inflammation research · 2026Review
- Pipelines for lymphocyte homeostasis maintenance during cancer immunotherapy.Frontiers in immunology · 2025Review
- Visualizing the Tumor Microenvironment: Molecular Imaging Probes Target Extracellular Matrix, Vascular Networks, and Immunosuppressive Cells.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The immune regulatory role of lymphangiogenesis in kidney disease.Journal of translational medicine · 2024Review
- Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells.Scientific reports · 2024Article
- Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies.Experimental hematology & oncology · 2024Review
- Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes.Science immunology · 2024Article
- Lymphatic vessels in the age of cancer immunotherapy.Nature reviews. Cancer · 2024Review
- Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming.European journal of immunology · 2024Article
- Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease.Journal of clinical medicine · 2024Review
- Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells.Research square · 2024Article
- Understanding the development, pathogenesis, and injury response of meningeal lymphatic networks through the use of animal models.Cellular and molecular life sciences : CMLS · 2023Review
- Locally sourced: site-specific immune barriers to metastasis.Nature reviews. Immunology · 2023Review
- Barriers to immune cell infiltration in tumors.Journal for immunotherapy of cancer · 2023Review
- T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control.Nature immunology · 2023Article
- Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd - 4th, 2021, Italy).Journal of translational medicine · 2022Article
- Immune Potential Untapped: Leveraging the Lymphatic System for Cancer Immunotherapy.Cancer immunology research · 2022Review
- Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin.The Journal of experimental medicine · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Lymphatic vessels provide an anatomical framework for immune surveillance and adaptive immune responses. Although appreciated as the route for Ag and dendritic cell transport, peripheral lymphatic vessels are often not considered active players in immune surveillance. Lymphatic vessels, however, integrate contextual cues that directly regulate transport, including changes in intrinsic pumping and capillary remodeling, and express a dynamic repertoire of inflammatory chemokines and adhesion molecules that facilitates leukocyte egress out of inflamed tissue. These mechanisms together contribute to the course of peripheral tissue immunity. In this review, we focus on context-dependent mechanisms that regulate fluid and cellular transport out of peripheral nonlymphoid tissues to provide a framework for understanding the effects of afferent lymphatic transport on immune surveillance, peripheral tissue inflammation, and adaptive immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.