Evidence map›Paper›PMID 33397650›Full record

ArticleAntimicrobial agents and chemotherapy2021

An Integrated HOCl-Producing E-Scaffold Is Active against Monomicrobial and Polymicrobial Biofilms.

Laure Flurin, Yash S Raval, Abdelrhman Mohamed, Kerryl E Greenwood-Quaintance, Edison J Cano, Haluk Beyenal, Robin Patel

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. HOCl-producing electrochemical bandage for treatingAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
  7. Advanced therapeutics · 2023
    Article
  8. Antimicrobial agents and chemotherapy · 2023
    Article
  9. Article
  10. Article
  11. Microbiology spectrum · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Laure FlurinDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5687-1081
Yash S RavalDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-1161-4000
Abdelrhman MohamedThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-2132-0487
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Edison J CanoDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-0154-2544
Haluk BeyenalThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, USA.
Robin PatelDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.ORCID 0000-0001-6344-4141
Mayo Clinic · USWashington State University · USMayo Clinic in Florida · US

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
NIAID NIH HHS R01 AI091594
6 · The paper itself

Abstract

Oxidizing agents like hypochlorous acid (HOCl) have antimicrobial activity. We developed an integrated electrochemical scaffold, or e-scaffold, that delivers a continuous low dose of HOCl aimed at targeting microbial biofilms without exceeding concentrations toxic to humans as a prototype of a device being developed to treat wound infections in humans. In this work, we tested the device against 33 isolates of bacteria (including isolates with acquired antibiotic resistance) grown as

Indexed as

Hypochlorous AcidWound InfectionAnti-Bacterial AgentsBacteriaBiofilmsHumansAnti-Bacterial AgentsHypochlorous Acidbiofilmelectrochemistryhypochlorous acidtreatmentwound infections

Identifiers

PMID33397650
PMCPMC8092506
OpenAlexW3118245680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.