Evidence map›Paper›PMID 33397476›Full record

ReviewJournal of medical case reports2021

The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature.

Moayed Ibrahim, Kshama Bhyravabhotla, Basil Khalaf, Keith Van Meter, Nakhle S Saba, Hana Safah, Francisco Socola

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Moayed IbrahimSection of Hematology and Medical Oncology, Deming Department of Medicine, School of Medicine, Tulane University, 1430 Tulane Ave., Mailbox#8078, New Orleans, LA, 70112-2699, USA. mibrahim1@tulane.edu.ORCID http://orcid.org/0000-0003-0355-2380
Kshama BhyravabhotlaSection of Pediatrics-Internal Medicine, Deming Department of Medicine, Tulane University, New Orleans, LA, USA.
Basil KhalafSection of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Louisiana State University, New Orleans, LA, USA.
Keith Van MeterSection of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Louisiana State University, New Orleans, LA, USA.
Nakhle S SabaSection of Hematology and Medical Oncology, Deming Department of Medicine, School of Medicine, Tulane University, 1430 Tulane Ave., Mailbox#8078, New Orleans, LA, 70112-2699, USA.
Hana SafahSection of Hematology and Medical Oncology, Deming Department of Medicine, School of Medicine, Tulane University, 1430 Tulane Ave., Mailbox#8078, New Orleans, LA, 70112-2699, USA.
Francisco SocolaSection of Hematology and Medical Oncology, Deming Department of Medicine, School of Medicine, Tulane University, 1430 Tulane Ave., Mailbox#8078, New Orleans, LA, 70112-2699, USA.
Tulane University · USLouisiana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, there are only a few case reports of cyclophosphamide (Cy)-induced hemorrhagic cystitis (HC) in adult or pediatric allogeneic stem cell transplant (SCT) patients treated successfully with hyperbaric oxygen (HBO). In all the reported cases, Cy was used as a part of the conditioning regimen, rather than post-transplant for graft-versus-host-disease (GVHD) prophylaxis. More recently, the risk of HC in allogeneic SCT is further increased by the widespread use of post-transplantation cyclophosphamide (PTCy) as a highly effective strategy for GVHD prophylaxis. This is the first case reported of PTCy-induced HC successfully treated with HBO to the best of our knowledge. CASE PRESENTATION: In this article, we present a 58-year-old Caucasian male case of allogeneic SCT complicated by severe HC following PTCy, which was successfully treated with HBO, eliminating the need for cystectomy.

conclusionHBO can be a safe, noninvasive, alternative treatment modality for PTCy-induced HC developing in allogeneic SCT patients.

Indexed as

CystitisGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHyperbaric OxygenationAdultChildCyclophosphamideHumansMaleMiddle AgedCyclophosphamideAcute myeloid leukemiaCase reportCyclophosphamideGraft-versus-host disease prophylaxisHemorrhagic cystitisPost-transplant

Identifiers

PMID33397476
PMCPMC7784006
OpenAlexW3120631687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.