ArticleCancer cell international2021
Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk.
Article in Cancer cell international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Combination strategies to overcome drug resistance in FLTCancer cell international · 2023Article
- Identification and validation of TME-related signatures to predict prognosis and response to anti-tumor therapies in skin cutaneous melanoma.Functional & integrative genomics · 2023Article
- CD44 in Bone Metastasis Development: A Key Player in the Fate Decisions of the Invading Cells?Clinical & experimental metastasis · 2023Review
- Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk.Open medicine (Warsaw, Poland) · 2023Article
- Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompatibility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs.Current drug metabolism · 2022Article
- SOX9: Advances in Gynecological Malignancies.Frontiers in oncology · 2021Review
- circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3.Analytical cellular pathology (Amsterdam) · 2021Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.
methodsFive SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.
resultsThe SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.
conclusionThe NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
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